Using antibiotics to prevent bladder infections after Botox treatment

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the effectiveness of prophylactic antibiotics, specifically Ciprofloxacin, in reducing postoperative bladder infections following Botox injections for idiopathic overactive bladder in women. Participants will be randomly assigned to receive either the antibiotic or a placebo for three days after the procedure. The study will monitor the incidence of bladder infections and any side effects over a six-week follow-up period. Urine cultures will be collected to confirm infections, and a questionnaire will assess urinary symptoms and adverse events.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients with idiopathic OAB diagnosed clinically who have failed medical management
* Female
* Age ≥ 18

Exclusion Criteria:

* Patients with neurogenic OAB (OAB with potential underlying neurologic cause - multiple sclerosis, spinal cord injury, Parkinson's disease, other)
* Contraindication to injection of Botox - hypersensitivity to any botulinum toxin preparation or to any of the components in the formulation, current urinary tract infection, symptomatic urinary retention or PVR \> 200 mL, unwillingness or inability to initiate CIC post-treatment if required.
* Contraindication to oral Ciprofloxacin - hypersensitivity or allergy to Ciprofloxacin or other fluoroquinolone, concurrently taking Tizanidine or Agomelatine.14
* Active antibiotic therapy for any indication at the time of Botox injection - increased risk of adverse reaction with combining antibiotics, reduced risk of UTI with additional antibiotic.
* Male
* Age \< 18
* Pregnant and/or breastfeeding

Where it's running

• Urogynecology Clinic - Royal Alexandra Hospital
  Edmonton, Alberta, Canada Recruiting

Study contacts

• Study coordinator: Erin Kelly, MD FRCSC
• Email: eckelly@ualberta.ca
• Phone: 780-735-5290

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.