Using ANI-guided analgesia to improve bowel recovery after colorectal surgery
Effects of Analgesia Nociception Index (ANI)-Guided Analgesia on Postoperative Bowel Function Recovery in Laparoscopic Colorectal Surgery: A Prospective Randomized-controlled Study
This study tests if adjusting pain medication based on a special monitoring system can help people recover their bowel function faster after colorectal surgery compared to regular monitoring methods.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 80 (estimated) |
| Ages | 19 Years and up |
| Sex | All |
| Sponsor | Gangnam Severance Hospital Academic / other |
| Locations | 1 site (Seoul) |
| Trial ID | NCT05122078 on ClinicalTrials.gov |
What this trial studies
This clinical trial investigates the impact of Analgesia Nociception Index (ANI)-guided analgesia on the recovery of bowel function following laparoscopic colorectal surgery. Patients will be randomly assigned to either an ANI group, where the remifentanil infusion rate is adjusted based on ANI monitoring, or a Control group, where adjustments are made using traditional blood pressure and heart rate monitoring. The study aims to evaluate and compare bowel function recovery between these two groups post-surgery.
Who should consider this trial
Good fit: Ideal candidates are adults over 19 years old scheduled for laparoscopic colorectal surgery due to colorectal cancer.
Not a fit: Patients undergoing emergency surgery or those with certain medical histories, such as arrhythmias or chronic opioid use, may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could lead to improved bowel recovery times for patients undergoing colorectal surgery.
How similar studies have performed: While the ANI-guided approach is relatively novel, similar studies have shown promising results in optimizing analgesia and improving postoperative outcomes.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients over 19 years who undergo laparoscopic colorectal surgery for colorectal cancer at Gangnam Severance Hospital, Seoul, South Korea. Exclusion Criteria: * Emergency surgery * Patients with history of open abdominal surgery * Patients with arrhythmia * Patients with pacemaker insertion * Patients with history of heart transplantation * Patients taking medications that may affect ANI (antimuscarinics, alpha-agonists, beta blockers) * Patients with chronic opioid medication. * Cognitive impairment * Unable to read consent form (eg illiterate, foreigner, etc.)
Where this trial is running
Seoul
- GangnamSeverance Hospital — Seoul, South Korea (Recruiting)
Study contacts
- Study coordinator: Young Song
- Email: NEARMYHEART@yuhs.ac
- Phone: 82-2-2019-3520
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.