Using an algorithm to improve fluid treatment in sepsis patients
Precision Resuscitation With Crystalloids in Sepsis (PRECISE)
NA · Emory University · NCT06253585
This study tests whether using a special alert system to change the type of fluids given to adults with sepsis in the emergency department can help them get better outcomes.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 2002 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Emory University (other) |
| Locations | 7 sites (Atlanta, Georgia and 6 other locations) |
| Trial ID | NCT06253585 on ClinicalTrials.gov |
What this trial studies
This study investigates the effectiveness of an algorithm that alerts clinicians to switch from normal saline to balanced crystalloids for patients with sepsis who are at high risk of mortality. The algorithm is based on vital signs and is applied to adult patients in the emergency department who have a blood culture order. Patients classified as Group D will be randomized to receive either usual care or the intervention, which aims to enhance early fluid resuscitation choices. The goal is to determine if this approach can lead to better outcomes for patients with sepsis.
Who should consider this trial
Good fit: Ideal candidates are adult patients presenting to the emergency department with a suspicion of infection and a blood culture order who are classified as Group D.
Not a fit: Patients who do not have a blood culture order or are not classified as Group D may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could significantly reduce mortality rates in sepsis patients by optimizing fluid resuscitation strategies.
How similar studies have performed: Previous studies have shown mixed results regarding fluid types in sepsis, making this approach novel and potentially impactful.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * All adult patients presenting to the Emergency Department, with a blood culture order in the Emergency Department, who are classified as Group D, in whom a clinician initiates a normal saline order Exclusion Criteria: * None
Where this trial is running
Atlanta, Georgia and 6 other locations
- Emory Midtown Hospital — Atlanta, Georgia, United States (RECRUITING)
- Emory Saint Joseph's Hospital — Atlanta, Georgia, United States (RECRUITING)
- Emory Healthcare System — Atlanta, Georgia, United States (RECRUITING)
- Emory Hospital — Atlanta, Georgia, United States (RECRUITING)
- Emory Decatur Hospital — Decatur, Georgia, United States (RECRUITING)
- Emory Johns Creek Hospital — Johns Creek, Georgia, United States (RECRUITING)
- Emory Hillandale Hospital — Lithonia, Georgia, United States (RECRUITING)
Study contacts
- Principal investigator: Sivasubramanium Bhavani, MD — Emory University
- Study coordinator: Sivasubramanium Bhavani, MD
- Email: sivasubramanium.bhavani@emory.edu
- Phone: 404-712-2970
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Sepsis, Algorithm, Fluids, Infection, Crystalloids, Normal Saline