Using aminophylline to improve ureteral access for kidney stones
Efficacy of Intra-Ureteric Aminophylline Installation After Failed Stone Accessibility by Semi-rigid Ureteroscopy. Prospective Trial
This study is testing if using aminophylline can help people who have had trouble with kidney stone removal through a specific procedure to make it easier and safer.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 300 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Al-Azhar University Academic / other |
| Locations | 1 site (Cairo) |
| Trial ID | NCT06728943 on ClinicalTrials.gov |
What this trial studies
This study investigates the effectiveness of local intraureteric aminophylline instillation in patients who have previously experienced failed access to ureteric stones via semi-rigid ureteroscopy. The approach aims to facilitate stone removal without the need for balloon dilation, potentially reducing complications associated with ureteroscopy. By relaxing smooth muscle and alleviating inflammation, aminophylline may enhance the success rate of ureteroscopic procedures. The study will include patients who meet specific criteria and will be conducted at Al-Azhar University in Cairo.
Who should consider this trial
Good fit: Ideal candidates are patients who have experienced failed stone accessibility by semi-rigid ureteroscopy.
Not a fit: Patients who are children, have contraindications to aminophylline, or have active urinary tract infections will not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could improve the success rate of ureteroscopic procedures for patients with ureteric stones.
How similar studies have performed: While the use of aminophylline in this context is novel, similar studies have explored its effects in other urological applications, indicating potential for success.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * The study will include patients with failed stone accessibility by semi-rigid ureteroscopy. Exclusion Criteria: * Child age group * Pre stented patients * Contraindications to aminophylline (hypersensitivity to drug components, pregnancy or lactation ,…) * Contraindications to ureteroscopy (active urinary tract infection - Contraindications to general or spinal anesthesia - Uncorrected bleeding disorders)
Where this trial is running
Cairo
- Al-Azhar university, faculty of medicine, the urology department — Cairo, Egypt (Recruiting)
Study contacts
- Study coordinator: Mohamed Fawzy Mohamed Fawzy Salman, MD
- Email: prof_mohamed_fawzy@yahoo.com
- Phone: +201111788996
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.