Using AK104 with chemotherapy for lung cancer treatment

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study evaluates the efficacy and safety of AK104, a bispecific antibody targeting PD-1 and CTLA-4, in combination with chemotherapy for patients with resectable stage II-IIIA non-small cell lung cancer (NSCLC). Participants will receive AK104 along with Albumin-Bound Paclitaxel and Carboplatin as both neoadjuvant and adjuvant therapy. The goal is to improve treatment outcomes while enhancing safety compared to traditional therapies. The study will assess measurable lesions to determine the effectiveness of the treatment.

Why it matters

Who can join: the full rules

Key Inclusion Criteria:

1. Eastern Cooperative Oncology Group (ECOG) Performance Status of 0 or 1.
2. Have previously untreated and pathologically confirmed resectable Stage II-IIIA NSCLC.
3. Have at least one measurable lesion per RECIST 1.1 assessed by investigator.
4. Have adequate organ function.

Key Exclusion Criteria:

1. Mixed NSCLC and small cell lung cancer histology.
2. Patients with other active malignancies within 3 years prior to enrollment.
3. Known active autoimmune diseases.
4. Use of immunosuppressive agents within 14 days prior to the first dose of study treatment.
5. Presence of other uncontrolled serious medical conditions.

Where it's running

• Henan Cancer Hospital
  Zhengzhou, Henan, China Recruiting

Study contacts

• Study coordinator: Huijuan Wang, MD
• Email: 18638561588@163.com
• Phone: 18638561588

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.