Using airway fluid to identify biomarkers for lung cancer recurrence
Extracellular Vesicles and Particles (EVP) as Biomarkers of Recurrence in Non-Small Cell Lung Cancer
This study is testing if fluid collected from the lungs during surgery can help find markers that show if lung cancer is likely to come back in patients with non-small cell lung cancer.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 200 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Memorial Sloan Kettering Cancer Center Academic / other |
| Drugs / interventions | radiation |
| Locations | 7 sites (Basking Ridge, New Jersey and 6 other locations) |
| Trial ID | NCT05424029 on ClinicalTrials.gov |
What this trial studies
This observational study aims to investigate whether bronchial washing samples collected during routine surgeries for non-small cell lung cancer (NSCLC) contain extracellular vesicles that can serve as biomarkers for cancer recurrence. By analyzing these samples, researchers hope to gain insights into the biological characteristics of NSCLC and improve understanding of the disease. The study will include patients aged 18 and older who are undergoing surgical resection for primary lung cancer, with specific criteria for inclusion and exclusion based on their medical history and current health status.
Who should consider this trial
Good fit: Ideal candidates for this study are adults aged 18 and older who are scheduled for surgical resection of primary non-small cell lung cancer.
Not a fit: Patients with active infections or pneumonia that could affect the analysis of bronchial washings may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved methods for predicting lung cancer recurrence, allowing for better patient management.
How similar studies have performed: While the use of extracellular vesicles as biomarkers is a growing field, this specific approach in the context of NSCLC is relatively novel and has not been extensively tested in prior studies.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * All patients ≥ 18 years of age undergoing consideration of surgical resection, including lobar resections, sublobar resections, and pneumonectomies, for primary lung cancer will be eligible. * Patients with previously resected disease and/or previous radiation therapy will be considered on a case by case basis. Exclusion Criteria: * Patients with active infection or pneumonia which may impact exosome makeup * Additionally, if at the discretion of the operating surgeon, obtaining bronchial washings would lead to undue morbidity, the patient would be excluded and replaced
Where this trial is running
Basking Ridge, New Jersey and 6 other locations
- Memorial Sloan Kettering Basking Ridge (Consent Only) — Basking Ridge, New Jersey, United States (Recruiting)
- Memorial Sloan Kettering Monmouth (Consent Only) — Middletown, New Jersey, United States (Recruiting)
- Memorial Sloan Kettering Bergen (Consent Only) — Montvale, New Jersey, United States (Recruiting)
- Memorial Sloan Kettering Suffolk - Commack (Consent Only) — Commack, New York, United States (Recruiting)
- Memorial Sloan Kettering Westchester (Consent Only) — Harrison, New York, United States (Recruiting)
- Memorial Sloan Kettering Cancer Center — New York, New York, United States (Recruiting)
- Memorial Sloan Kettering Nassau (Consent Only) — Uniondale, New York, United States (Recruiting)
Study contacts
- Principal investigator: David Jones, MD — Memorial Sloan Kettering Cancer Center
- Study coordinator: David Jones, MD
- Email: jonesd2@mskcc.org
- Phone: 212-639-6428
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.