Using air-polishing with erythritol to prevent gum inflammation and white spots during orthodontic treatment

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial evaluates the effectiveness of an air-polishing device using erythritol powder compared to the conventional ultrasonic scaler in preventing white spot lesions (WSLs) and gingivitis in young patients undergoing multi-bracketed fixed orthodontic treatment. The study involves 60 participants aged 12 to 16, who will be randomly assigned to receive either air-polishing or ultrasonic treatment during their orthodontic appointments over a period of two years. Clinical examinations and sample collections will occur at regular intervals to assess the prevalence of WSLs and gingivitis, as well as the antimicrobial efficacy against periodontal pathogens. The primary aim is to determine if air-polishing can serve as a viable monotherapy for these conditions.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Subjects about to undergo fixed orthodontic treatment will be invited to participate.
* Age between 12 and 16 years only participants
* Informed written consent obtained by the parents

Exclusion Criteria:

* Clinically significant concomitant disease states (e.g., renal failure, hepatic dysfunction, cardiovascular disease, etc.),
* Known or suspected non-compliance, drug or alcohol abuse
* Inability to follow the procedures of the investigation, e.g. due to language problems, psychological disorders, dementia, etc. of the subject
* Participation in another investigation with an investigational drug or another MD within the 30 days preceding and during the present investigation
* Previous enrolment into the current investigation
* Enrolment of the PI, his/her family members, employees and other dependent persons
* History of fixed orthodontic treatment
* Defects on enamel on labial surfaces of the teeth
* Untreated cavitated lesions
* Plaque levels \>25%
* Periodontitis
* Multiple missing teeth
* Cleft lip and/or palate or other craniofacial anomalies or syndromes
* Patients taking any regular medication
* Patients with asthmatic problems

Where it's running

• University of Geneva, University Clinics of Dental Medicine
  Geneva, Canton of Geneva, Switzerland Recruiting

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Comparing two treatments for white spot lesions in children

  This study tests two different treatments for white spot lesions on kids' teeth to see which one works better for improving their appearance and health.

  Recruiting Early Phase 1 October 6 University · Cairo, Giza Governorate · NCT06708481

• Vitamin D supplementation for dental caries treatment

  This study is testing whether vitamin D supplements can help people aged 12 to 45 with early tooth decay get better compared to those using fluoride treatments.

  Recruiting Phase 4 Dow University of Health Sciences · Karachi, Sindh · NCT06172764

• Biomin fluoride varnish vs. Duraphat, with or without diode laser, for white spot lesions in primary teeth

  This trial tests whether Biomin fluoride varnish, alone or with diode laser, can better remineralize white spot lesions in young children than standard Duraphat varnish.

  Recruiting at 2 sites Alexandria University · Alexandria, Alexandria Governorate and 1 other locations · NCT07845110

• Epinamel Gel for Rebuilding White Spot Lesions Around Braces

  A gel called Epinamel is being tested to see if it can help white spot lesions around braces regain enamel strength and appearance in teens and adults.

  Recruiting Mintech Bio Ltd · London · NCT07730359

• How braces affect the mouth microbiome and saliva proteins in teens

  This study follows teens starting orthodontic treatment to see how their mouth bacteria and saliva proteins change over time.

  Recruiting Xi'an Jiaotong University · Xi'an, Shaanxi · NCT06824493

• Preventive Potential of Fluoride Sealants in Adolescent Orthodontic Patients

  In teens getting braces, this study tests whether a fluoride-releasing bonding agent on one side of the upper jaw can reduce white spots compared with the regular bonding agent used on the other side after 3 months.

  Recruiting Sigmund Freud PrivatUniversitat · Vienna · NCT07691879

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.