Using AI with Ultrasound to Detect Endometrial Cancer in Post-Menopausal Women
Official title: Non-Invasive Identification of Endometrial Cancer/Endometrial Atypical Hyperplasia With an AI-Based Classifier Applied to Transvaginal Ultrasound in Patients With Post-Menopausal Bleeding
Run by Mayo Clinic · NCT06365905 · Data updated 2026-11-12
This study is testing whether an AI program can help find endometrial cancer in women over 55 who have had postmenopausal bleeding by looking at ultrasound images.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 55 Years and up |
| Sex | Women only |
| Enrollment | 300 (estimated) |
| Sponsor | Mayo Clinic Academic / other |
| Locations | 3 sites (Scottsdale, Arizona and 2 other locations) |
| Status | Recruiting |
| Started | March 27, 2024 |
| Main results expected | June 30, 2027 |
| Study ends | June 30, 2027 |
| Registry record updated | June 10, 2026 |
| Trial ID | NCT06365905 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are women aged 55 and older who have experienced at least one episode of postmenopausal bleeding.
✕Probably not a fit
Patients who have had diagnostic tests performed more than 90 days apart or those unable to undergo a transvaginal ultrasound may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to validate an artificial intelligence (AI) algorithm that analyzes transvaginal ultrasound (TVUS) images to identify women with endometrial cancer or premalignant lesions. Participants will undergo a TVUS examination and have their medical records reviewed, including endometrial biopsy results. The study focuses on women aged 55 and older who have experienced postmenopausal bleeding, assessing the effectiveness of AI in early detection.
Why it matters
Potential benefit: If successful, this approach could lead to earlier and more accurate detection of endometrial cancer, improving patient outcomes.
How similar studies have gone: Other studies have shown promise in using AI for medical imaging, suggesting potential success for this novel approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age ≥ 55 years * At least one episode of postmenopausal bleeding (PMB) * Endometrial biopsy available from at Mayo Clinic (MN, AZ, FL), Mayo Clinic Health System (MCHS), or an external institution * Acceptance to participate in the study Exclusion Criteria: * Diagnostic tests performed more than 90 days apart * Physical impediment/refusal to undergo transvaginal ultrasound (TVUS)
Where it's running
-
Mayo Clinic in Arizona
Scottsdale, Arizona, United States Recruiting -
Mayo Clinic in Florida
Jacksonville, Florida, United States Recruiting -
Mayo Clinic in Rochester
Rochester, Minnesota, United States Recruiting
Study contacts
- Principal investigator: Gretchen E Glaser, MD — Mayo Clinic in Rochester
- Study coordinator: Clinical Trials Referral Office
- Email: mayocliniccancerstudies@mayo.edu
- Phone: 855-776-0015
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.