Using AI to recommend treatments for adults with skeletal Class III malocclusion

Reliability Of Artificial Intelligence for Treatment Decision Recommendation of Adult Skeletal Class III Patients: A Diagnostic Test Accuracy Study

Observational Cairo University · NCT06002373

This study is testing whether artificial intelligence can give better treatment suggestions for adults with jaw and dental issues caused by skeletal Class III malocclusion.

Quick facts

Study typeObservational
Enrollment150 (estimated)
Ages18 Years and up
SexAll
SponsorCairo University Academic / other
Locations1 site (Cairo)
Trial IDNCT06002373 on ClinicalTrials.gov

What this trial studies

This study assesses the reliability of artificial intelligence in providing treatment recommendations for adult patients with skeletal Class III malocclusion, a condition characterized by facial and dental irregularities due to jaw discrepancies. It involves collecting a diverse dataset of adult patients diagnosed with this condition and training AI algorithms on various clinical and radiographic parameters to identify patterns. The AI-generated recommendations will be compared to traditional treatment planning methods to evaluate their accuracy and dependability.

Who should consider this trial

Good fit: Ideal candidates are skeletally mature adults diagnosed with skeletal Class III malocclusion who have not undergone previous surgical interventions.

Not a fit: Patients who are skeletally immature, have pseudo class III, or present with syndromic conditions may not benefit from this study.

Why it matters

Potential benefit: If successful, this approach could lead to more accurate and personalized treatment plans for patients with skeletal Class III malocclusion.

How similar studies have performed: While the use of AI in orthodontics is emerging, this specific application for skeletal Class III malocclusion treatment recommendations is relatively novel and has not been extensively tested in prior studies.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Skeletally mature patients with CVMI 6.
* Skeletal class III patients
* No congenital deformity, syndrome, or cleft.
* No previous surgical intervention
* No mandibular transverse functional shift.
* Normal overjet, overbite after completion of treatment.
* Patients with well finished occlusion.
* Patients who have achieved adequate functional and aesthetic results at the end of their treatment.
* Good quality initial and final lateral cephalometric radiographs.
* No sex predilection.

Exclusion Criteria:

* Adolescents and skeletally immature patients.
* Patients with pseudo class III.
* Syndromic patients.
* Patients with facial deformity at the naso-maxillary complex

Where this trial is running

Cairo

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions Skeletal DysplasiaReverse Overjet
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.