Using AI to recognize benign vocal fold lesions

Artificial Intelligence for the Recognition of Benign Lesions of Vocal Folds From Audio Recordings

Observational Fondazione Policlinico Universitario Agostino Gemelli IRCCS · NCT05754606

This study is testing if artificial intelligence can help identify different types of benign vocal fold lesions by analyzing voice recordings from people with voice problems.

Quick facts

Study typeObservational
Enrollment300 (estimated)
Ages18 Years to 65 Years
SexAll
SponsorFondazione Policlinico Universitario Agostino Gemelli IRCCS Academic / other
Locations1 site (Roma)
Trial IDNCT05754606 on ClinicalTrials.gov

What this trial studies

This observational study aims to utilize artificial intelligence to analyze audio recordings of patients with dysphonia caused by benign lesions of the vocal folds. Participants will be asked to pronounce a specific word multiple times, and their voice samples will be categorized based on the type of vocal fold lesion diagnosed endoscopically. The study will employ advanced audio signal analysis techniques to extract various acoustic features from the recordings, which will then be analyzed to identify potential vocal biomarkers for diagnosis and classification of voice disorders.

Who should consider this trial

Good fit: Ideal candidates for this study are individuals diagnosed with benign lesions of the vocal folds, such as Reinke's edema, cysts, nodules, or polyps.

Not a fit: Patients who have undergone previous laryngeal or thyroid surgery, speech therapy, or have current pulmonary diseases or laryngeal movement disorders may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could lead to improved diagnostic methods for vocal fold lesions, enhancing clinical practice and patient outcomes.

How similar studies have performed: While the application of AI in voice analysis is a growing field, this specific approach focusing on benign vocal fold lesions is relatively novel and has not been extensively tested in prior studies.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion criteria:

* Reinke's edema
* cyst of the vocal fold
* nodule of the vocal fold
* polyp of the vocal fold

Exclusion criteria:

* previous laryngeal or thyroid surgery
* previous speech therapy
* current pulmonary diseases
* current gastroesophageal reflux
* laryngeal movement disorder or recurrent laryngeal nerve paralysis
* Non-native Italian speakers

Where this trial is running

Roma

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions Dysphonia
Last reviewed 2026-06-09 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.