Using AI to help patients with first episode psychosis take their medication

Early-phase Schizophrenia: Practice-based Research to Improve Outcomes (ESPRITO) - Using Artificial Intelligence to Measure Adherence to Oral Medication

Phase 4 Interventional Northwell Health · NCT04046497

This study tests whether an AI smartphone app can help people experiencing their first episode of psychosis remember to take their medication better than standard care.

Quick facts

PhasePhase 4
Study typeInterventional
Enrollment200 (estimated)
Ages15 Years to 40 Years
SexAll
SponsorNorthwell Health Academic / other
Locations5 sites (Hialeah, Florida and 4 other locations)
Trial IDNCT04046497 on ClinicalTrials.gov

What this trial studies

This project aims to utilize an artificial intelligence smartphone app to enhance medication adherence among patients experiencing their first episode of psychosis. The study addresses the significant challenge of non-adherence to oral medications, which is linked to higher rates of relapse and hospitalization. By comparing the outcomes of participants using the AI app to those receiving standard care, the study seeks to evaluate the app's acceptability and its impact on hospitalization and emergency room visits. The approach is inspired by successful monitoring techniques used in other medical fields, adapted for community settings.

Who should consider this trial

Good fit: Ideal candidates for this study are individuals enrolled in a Coordinated Specialty Care (CSC) program who have been prescribed an oral antipsychotic.

Not a fit: Patients who are not enrolled in a CSC program or those not prescribed oral antipsychotics may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could significantly improve medication adherence and reduce hospitalization rates for patients with first episode psychosis.

How similar studies have performed: Other studies have shown success with similar approaches in different medical fields, indicating potential for this novel application in mental health.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Enrolled in a CSC program
* Prescribed an oral antipsychotic

Exclusion Criteria:

* none

Where this trial is running

Hialeah, Florida and 4 other locations

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions First Episode Psychosis
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.