Using AI to analyze heart transplant rejection through echocardiograms
Official title: Outcome Reflection for Immune Mediated Rejection by Utilizing Artificial Intelligence in Cardiac Transplant Patients Through Early and Late Echocardiographic Analysis (ORACLE)
Run by Mayo Clinic · NCT06178744 · Data updated 2026-11-12
This study is testing if an AI program can help doctors better spot heart transplant rejection by looking at echocardiograms and ECGs from patients who have had a heart transplant.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 500 (estimated) |
| Sponsor | Mayo Clinic Academic / other |
| Locations | 1 site (Rochester, Minnesota) |
| Status | Recruiting |
| Started | April 4, 2024 |
| Main results expected | June 2027 |
| Study ends | June 2028 |
| Registry record updated | June 24, 2026 |
| Trial ID | NCT06178744 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are patients who have recently undergone a cardiac transplant and are scheduled for endomyocardial biopsy.
✕Probably not a fit
Patients who refuse to participate in the study will not benefit from the findings.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This research aims to improve the detection of cardiac transplant rejection by utilizing an Artificial Intelligence (AI) algorithm that analyzes data from electrocardiograms (ECGs) and echocardiograms. The study will observe patients undergoing endomyocardial biopsy after cardiac transplant to assess the accuracy of the AI in distinguishing between rejection and non-rejection episodes. By leveraging advanced technology, the study seeks to enhance diagnostic capabilities in post-transplant care.
Why it matters
Potential benefit: If successful, this approach could lead to more accurate and timely detection of cardiac transplant rejection, improving patient outcomes.
How similar studies have gone: While the use of AI in medical diagnostics is a growing field, this specific application in cardiac transplant rejection detection is relatively novel and has not been extensively tested in prior studies.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients undergoing post-cardiac transplant endomyocardial biopsy, and the ability to provide informed consent and a consent for the study. Exclusion Criteria: * Refusal of study participation
Where it's running
-
Mayo Clinic in Rochester
Rochester, Minnesota, United States Recruiting
Study contacts
- Principal investigator: Atta Behfar, MD, PhD — Mayo Clinic
- Study coordinator: Alyssa Lokensgard
- Email: lokensgard.alyssa@mayo.edu
- Phone: 507-422-5123
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.