Using AI to analyze coronary CT scans for better patient risk assessment

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to enhance the identification of patients at risk for coronary artery disease (CAD) progression by applying artificial intelligence algorithms to coronary computed tomography angiography (cCTA) images. The researchers will extract periluminal radiomic features to characterize the atherosclerotic process, which is currently underutilized in clinical practice. By developing a novel AI-based risk score, the study seeks to improve risk stratification for patients with non-obstructive CAD, ultimately guiding more aggressive medical treatment for those identified as high-risk. The study will include patients who underwent cCTA for CAD assessment between 2017 and 2019 and have a follow-up duration of at least four years.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Patients with CT performed for CAD assessment between 2017 and 2019.
2. Follow-up duration of at least 4 years.

Exclusion Criteria:

1. Refusal to participate in the study
2. Age \<18 years old
3. History of previous coronary revascularization
4. Presence of other cardiovascular comorbidities (e.g. inflammatory cardiomyopathy, valvular cardiomyopathy, idiopathic dilated cardiomyopathy, infiltrative cardiomyopathy)

Where it's running

• IRCCS San Raffaele
  Milano, Italy Recruiting

Study contacts

• Study coordinator: Antonio Esposito
• Email: esposito.antonio@hsr.it
• Phone: 02 2643 6102

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.