Using advanced MRI techniques to analyze benign neuronal tumors
Multiparametric Imaging for Analysis of MVNT (Multinodular and Vacuolating Neuronal Tumor)
This study is testing if advanced MRI techniques can help doctors better identify benign neuronal tumors in adults to prevent unnecessary surgeries.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 50 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Fondation Ophtalmologique Adolphe de Rothschild Research network |
| Locations | 7 sites (Bordeaux and 6 other locations) |
| Trial ID | NCT04103190 on ClinicalTrials.gov |
What this trial studies
This observational study aims to improve the diagnosis of Multinodular and Vacuolating Neuronal Tumors (MVNT) by utilizing advanced MRI techniques, including spectroscopy. The study focuses on differentiating MVNT from other similar benign neuronal diseases, such as dysembryoplastic neuroepithelial tumors and low-grade gliomas, to avoid unnecessary surgical interventions. Patients over 18 years old with suspected MVNT based on specific MRI criteria will be included in the study. The research will assess the effectiveness of these imaging techniques in confirming the benign nature of the lesions.
Who should consider this trial
Good fit: Ideal candidates are adults over 18 years old with a suspicion of MVNT based on MRI findings.
Not a fit: Patients who are pregnant, lactating, or have contraindications to MRI will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to more accurate diagnoses of benign neuronal tumors, reducing the need for invasive surgeries.
How similar studies have performed: While advanced MRI techniques have been used in other contexts, this specific application for MVNT diagnosis is novel and has not been extensively studied.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patient over 18 years old * Suspicion of MVNT on an MRI: it is considered that it will be necessary at least the 2 major criteria associated with at least 1 minor criterion to enter the definition of suspicion of MVNT: Major criteria: * Multinodular aspect in cluster * High FLAIR hypersignal / T2 Minor criteria: * Absence of mass effect * Hyposignal T1 * Center of the lesion in hypsignal FLAIR or T1 hypersignal * Affiliate or beneficiary of a Social Security scheme * Having received informed information about the study and consenting to participate in the study Exclusion Criteria: * Patient benefiting from a legal protection measure * Pregnant or lactating woman * Contraindication to MRI
Where this trial is running
Bordeaux and 6 other locations
- Groupe Hospitalier Pellegrin — Bordeaux, France (Recruiting)
- Fondation Adolphe de Rothschild — Paris, France (Recruiting)
- Centre Hospitalier Lyon Sud — Pierre Bénite, France (Not_yet_recruiting)
- CHU Rennes — Rennes, France (Recruiting)
- CHU de Rouen — Rouen, France (Not_yet_recruiting)
- Hôpital Laennec — Saint-Herblain, France (Recruiting)
- Hôpital Pierre Paul Riquet, CHU Purpan — Toulouse, France (Recruiting)
Study contacts
- Study coordinator: Laurence Salomon, MD PhD
- Email: lsalomon@for.paris
- Phone: 0148036431
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.