Using advanced microscopy to improve skin cancer surgery outcomes
Investigation of Mohs Surgical Margins Using Two Photon Microscopy
This study is testing a new imaging technique during skin cancer surgery to see if it can better find leftover cancer cells compared to the usual method.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 92 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University of Rochester Academic / other |
| Locations | 1 site (Victor, New York) |
| Trial ID | NCT05814900 on ClinicalTrials.gov |
What this trial studies
This clinical trial investigates the effectiveness of two photon fluorescence microscopy (TPFM) in detecting residual basal cell carcinoma (BCC) during Mohs surgery. The study compares the accuracy of TPFM in evaluating surgical margins against the standard frozen section histology method. Patients undergoing Mohs surgery will have their excised tissue analyzed using TPFM, followed by traditional cryosectioning for confirmation. The goal is to determine if TPFM can provide reliable results that could potentially change patient care practices.
Who should consider this trial
Good fit: Ideal candidates are patients undergoing Mohs surgery for basal cell carcinoma.
Not a fit: Patients not undergoing Mohs surgery or those with conditions other than basal cell carcinoma may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could lead to more accurate detection of cancer margins, reducing the likelihood of residual cancer after surgery.
How similar studies have performed: While the use of two photon microscopy is a novel approach in this context, similar imaging techniques have shown promise in other studies for improving surgical outcomes.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Undergoing treatment for BCC with Mohs surgery at the performance site * Able to read and understand consent form Exclusion Criteria: * None
Where this trial is running
Victor, New York
- Rochester Dermatologic Surgery — Victor, New York, United States (Recruiting)
Study contacts
- Principal investigator: Michael G Giacomelli, Ph.D — University of Rochester
- Study coordinator: Michael G Giacomelli, Ph.D
- Email: mgiacome@ur.rochester.edu
- Phone: 5852766260
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.