Using advanced imaging to improve corneal surgery outcomes
Official title: Optical Coherence Tomography Guided Transepithelial Phototherapeutic Keratectomy
Run by Oregon Health and Science University · NCT01243931 · Data updated 2026-11-12
This study is testing whether using advanced imaging technology can help doctors perform better surgeries for people with corneal scars to improve their vision.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 80 (estimated) |
| Sponsor | Oregon Health and Science University Academic / other |
| Locations | 1 site (Portland, Oregon) |
| Status | Recruiting |
| Started | June 2011 |
| Main results expected | December 2026 |
| Study ends | December 2026 |
| Registry record updated | February 12, 2024 |
| Trial ID | NCT01243931 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are patients whose vision is primarily limited by superficial corneal opacities that can be treated with PTK.
✕Probably not a fit
Patients with deep corneal opacities, cataracts, or other significant eye conditions may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study aims to enhance the effectiveness of phototherapeutic keratectomy (PTK) for patients with corneal opacity by utilizing Optical Coherence Tomography (OCT) technology. The researchers will employ high-speed OCT to accurately measure the depth and shape of corneal scars and irregularities, guiding laser treatment to improve vision outcomes. By moving away from subjective assessments, this approach seeks to provide a more precise and reliable method for treating superficial corneal defects. The ultimate goal is to restore vision in patients with irregularly shaped corneas through improved surgical techniques.
Why it matters
Potential benefit: If successful, this approach could significantly improve vision restoration for patients with corneal opacities.
How similar studies have gone: Other studies utilizing advanced imaging techniques in ophthalmology have shown promising results, suggesting potential success for this novel approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients with vision primarily limited by superficial opacities and irregularities that could be removed by PTK while leaving at least 250 µm. Exclusion Criteria: * Inability to give informed consent * Inability to maintain stable fixation for OCT imaging * Inability to commit to required visits to complete the study * Deep corneal opacities and irregularities * Cataracts, retinal disease, glaucoma, or other eye conditions that may limit the visual outcome after surgery
Where it's running
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Casey Eye Institute, Oregon Health & Science University
Portland, Oregon, United States Recruiting
Study contacts
- Principal investigator: David Huang, MD, PhD — Casey Eye Institute, Oregon Health & Science University
- Study coordinator: Humberto Martinez, COT
- Email: martinhu@ohsu.edu
- Phone: 503-494-7712
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.