Using advanced imaging to improve cancer surgery outcomes

A Single Centre Pilot Study Investigating the Diagnostic Performance of High-resolution Specimen PET-CT in Determining Margin Status in Cancer Resection

This study is testing a new imaging tool to help surgeons better see cancer during surgery for prostate and head and neck cancers, aiming to improve patient outcomes and reduce the need for extra treatments.

Quick facts

• Phase: Not applicable
• Study type: Interventional
• Enrollment: 87 (estimated)
• Ages: 18 Years and up
• Sex: All
• Sponsor: University Hospitals Coventry and Warwickshire NHS Trust (Academic / other)
• Locations: 1 site (Coventry)
• Trial ID: NCT06676943 on ClinicalTrials.gov

What this trial studies

This study investigates the use of a high-resolution specimen PET-CT scanner to assess surgical margin status in patients undergoing cancer resections, specifically for prostate and head and neck cancers. The goal is to provide surgeons with more accurate information about the extent of cancerous tissue, potentially reducing the need for additional treatments and alleviating patient anxiety. By analyzing tumor specimens with this advanced imaging technique, the study aims to enhance surgical precision and patient outcomes. Eligible participants include those scheduled for specific cancer surgeries who meet the inclusion criteria.

Who should consider this trial

Good fit: Ideal candidates are adults over 18 scheduled for robotic radical prostatectomy or resection of oral squamous cell carcinoma.

Not a fit: Patients with contraindications for surgery or those currently participating in other interventional studies may not benefit from this study.

Why it matters

Potential benefit: If successful, this approach could lead to more effective cancer surgeries with fewer instances of residual cancer, improving patient outcomes.

How similar studies have performed: While this specific approach is novel, similar imaging techniques have shown promise in improving surgical outcomes in other cancer types.

Eligibility criteria

Inclusion Criteria:

For prostate cancer patients:

1. At least 18 years old at time of consent.
2. Listed for Robotic Radical Prostatectomy.

For head and neck cancer patients:

1. At least 18 years old at time of consent.
2. Listed for resection of oral squamous cell carcinoma head and neck cancer resection.
3. Specimen able to fit into Xeos Aura specimen container.

Exclusion Criteria:

For prostate cancer patients:

1. General or local contra-indications for resectional surgery.
2. Lacks capacity to provide informed consent.
3. Currently participating in another interventional research study that in the judgment of the investigator would negatively affect the participant and/or this study's data integrity.

For head and neck cancer patients:

1. General or local contra-indications for resectional surgery.
2. Lacks capacity to provide informed consent.
3. Pregnant or breast feeding patient.
4. Currently participating in another interventional research study that in the judgment of the investigator would negatively affect the participant and/or this study's data integrity.

Where this trial is running

Coventry

• University Hospitals Coventry and Warwickshire NHS Trust — Coventry, United Kingdom (Recruiting)

Study contacts

• Study coordinator: Oludolapo Adesanya

Conditions Prostate Cancer Surgery; Head and Neck Cancers; specimen PET-CT; surgical margin status