Using advanced imaging to distinguish brain tumor recurrence from treatment effects in children
Integrated PET/MRI and Germline Variants to Differentiate Brain Tumopr Recurrence From Iatrogenicchanges in Children
This study is testing if special imaging techniques can help doctors tell the difference between a returning brain tumor and changes caused by treatment in children who have had brain tumors.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 60 (estimated) |
| Ages | N/A to 18 Years |
| Sex | All |
| Sponsor | IRCCS San Raffaele Academic / other |
| Drugs / interventions | chemotherapy |
| Locations | 1 site (Milano) |
| Trial ID | NCT06226519 on ClinicalTrials.gov |
What this trial studies
This observational study aims to utilize integrated PET/MRI imaging alongside genetic analysis to improve the differentiation between brain tumor recurrence and iatrogenic changes in pediatric patients. By focusing on children and adolescents diagnosed with brain tumors who have undergone post-surgical chemotherapy and radiotherapy, the study seeks to address a critical clinical challenge in patient management. The approach combines advanced imaging techniques with germline variant analysis to enhance diagnostic accuracy and inform treatment decisions.
Who should consider this trial
Good fit: Ideal candidates for this study are children and adolescents aged 18 years or younger who have been diagnosed with a brain tumor and have received contemporary adjuvant therapy.
Not a fit: Patients older than 18 years will not benefit from this study as it specifically targets a pediatric population.
Why it matters
Potential benefit: If successful, this study could lead to more accurate diagnoses and better management of pediatric brain tumor patients, ultimately improving their outcomes.
How similar studies have performed: While this approach is innovative, similar studies utilizing advanced imaging techniques have shown promise in improving diagnostic accuracy in other contexts.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * children and/or adolescents (≤18 years) diagnosed with brain tumor. * children who underwent the contemporary adjuvant therapy protocol of post-surgical chemo and radiotherapy. Exclusion Criteria: * patients \>18 years
Where this trial is running
Milano
- Irccs San Raffaele — Milano, Italy (Recruiting)
Study contacts
- Study coordinator: Arturo Chiti
- Email: chiti.arturo@hsr.it
- Phone: 0226432716
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.