Using adenosine to understand the causes of premature ventricular contractions
Official title: Use of Adenosine to Determine the Electrophysiological Mechanism of Premature Ventricular Contractions
Run by Weill Medical College of Cornell University · NCT03218137 · Data updated 2026-11-12
This study is testing if giving adenosine and verapamil to patients can help doctors understand what causes premature ventricular contractions (PVCs) and how to better treat them.
Quick facts
| Phase | Phase 4 |
|---|---|
| Study type | Interventional |
| Ages | 18 Years to 70 Years |
| Sex | All |
| Enrollment | 100 (estimated) |
| Sponsor | Weill Medical College of Cornell University Academic / other |
| Locations | 1 site (New York, New York) |
| Status | Recruiting |
| Started | February 13, 2017 |
| Main results expected | December 31, 2027 |
| Study ends | December 31, 2027 |
| Registry record updated | June 23, 2026 |
| Trial ID | NCT03218137 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults aged 18 to 70 diagnosed with premature ventricular contractions who are scheduled for an electrophysiology study.
✕Probably not a fit
Patients with structural heart disease, significant coronary artery disease, or those currently on anti-arrhythmic drugs may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study investigates the electrophysiological mechanisms behind premature ventricular contractions (PVCs) by administering adenosine and verapamil to patients undergoing an electrophysiology study. It aims to determine if these substances can induce PVCs similarly to sustained ventricular tachycardia, thereby shedding light on the cellular mechanisms involved. The study will involve 100 subjects who have consented to participate in this controlled, non-randomized trial. The findings could lead to new therapeutic targets for treating PVCs and related arrhythmias.
Why it matters
Potential benefit: If successful, this study could provide insights that lead to improved treatments for patients suffering from PVCs.
How similar studies have gone: Other studies have shown success in using adenosine to understand arrhythmias, but this specific approach to PVCs is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Diagnosis of premature ventricular contractions (PVCs) * Scheduled to undergo an electrophysiology study with the intention of performing cardiac ablation for the treatment of PVCs * Male or female between the ages of 18 and 70 years * Capable of giving informed consent Exclusion Criteria: * Any structural heart disease * Coronary artery disease (≥ 70% stenosis) * Current treatment with anti-arrhythmic drugs * Pregnant * Asthma (if administering adenosine)
Where it's running
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Weill Cornell Medicine
New York, New York, United States Recruiting
Study contacts
- Principal investigator: James E Ip, M.D — Weill Medical College of Cornell University
- Study coordinator: James E Ip, M.D
- Email: jei9008@med.cornell.edu
- Phone: 212 746 2158
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Catheter ablation vs. anti-arrhythmic drugs for PVCs
This study tests whether catheter ablation or anti-arrhythmic medications are better at reducing PVC symptoms and improving quality of life for adults with a normal heart function.
-
Disrupted sleep and irregular heartbeats in people with hypoglossal nerve stimulators
This study will test whether turning a hypoglossal nerve stimulation (HGNS) device off for a night increases the chance of irregular heartbeats or short atrial fibrillation episodes in adults with obstructive sleep apnea who already have an HGNS implant.
-
Using flecainide to treat frequent premature ventricular contractions and related heart issues
This study is testing if the heart medication flecainide can help adults with frequent heartbeats and related heart issues who can't or don't want to have a procedure called catheter ablation.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.