Using adenosine to understand the causes of premature ventricular contractions
Use of Adenosine to Determine the Electrophysiological Mechanism of Premature Ventricular Contractions
This study is testing if giving adenosine and verapamil to patients can help doctors understand what causes premature ventricular contractions (PVCs) and how to better treat them.
Quick facts
| Phase | Phase 4 |
|---|---|
| Study type | Interventional |
| Enrollment | 100 (estimated) |
| Ages | 18 Years to 70 Years |
| Sex | All |
| Sponsor | Weill Medical College of Cornell University Academic / other |
| Locations | 1 site (New York, New York) |
| Trial ID | NCT03218137 on ClinicalTrials.gov |
What this trial studies
This study investigates the electrophysiological mechanisms behind premature ventricular contractions (PVCs) by administering adenosine and verapamil to patients undergoing an electrophysiology study. It aims to determine if these substances can induce PVCs similarly to sustained ventricular tachycardia, thereby shedding light on the cellular mechanisms involved. The study will involve 100 subjects who have consented to participate in this controlled, non-randomized trial. The findings could lead to new therapeutic targets for treating PVCs and related arrhythmias.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 to 70 diagnosed with premature ventricular contractions who are scheduled for an electrophysiology study.
Not a fit: Patients with structural heart disease, significant coronary artery disease, or those currently on anti-arrhythmic drugs may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide insights that lead to improved treatments for patients suffering from PVCs.
How similar studies have performed: Other studies have shown success in using adenosine to understand arrhythmias, but this specific approach to PVCs is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Diagnosis of premature ventricular contractions (PVCs) * Scheduled to undergo an electrophysiology study with the intention of performing cardiac ablation for the treatment of PVCs * Male or female between the ages of 18 and 70 years * Capable of giving informed consent Exclusion Criteria: * Any structural heart disease * Coronary artery disease (≥ 70% stenosis) * Current treatment with anti-arrhythmic drugs * Pregnant * Asthma (if administering adenosine)
Where this trial is running
New York, New York
- Weill Cornell Medicine — New York, New York, United States (Recruiting)
Study contacts
- Principal investigator: James E Ip, M.D — Weill Medical College of Cornell University
- Study coordinator: James E Ip, M.D
- Email: jei9008@med.cornell.edu
- Phone: 212 746 2158
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.