Using adaptive deep brain stimulation to improve exercise outcomes in Parkinson's Disease
Implementation of Adaptive DBS to Offset STN Dysregulation During Exercise and Reduce Exertion in Parkinson's Disease
University of Colorado, Denver · NCT06296810
This study is testing if a special brain device can help people with Parkinson's Disease exercise better and feel less symptoms while they do it.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 10 (estimated) |
| Ages | 20 Years to 70 Years |
| Sex | All |
| Sponsor | University of Colorado, Denver (other) |
| Locations | 1 site (Aurora, Colorado) |
| Trial ID | NCT06296810 on ClinicalTrials.gov |
What this trial studies
This study evaluates how exercise affects brain biomarkers in individuals with Parkinson's Disease using the PerceptTM PC neurostimulator. It focuses on measuring Local Field Potential biomarkers from the subthalamic nucleus during exercise. The study will also assess the feasibility of adaptive Deep Brain Stimulation (aDBS) to counteract the worsening of symptoms during and after exercise. Participants will be monitored to determine the effectiveness of this approach in managing their condition.
Who should consider this trial
Good fit: Ideal candidates are individuals with Parkinson's Disease who have a Medtronic DBS Sensight implant and a Percept IPG.
Not a fit: Patients without the specified DBS implant or those unable to participate in the exercise regimen may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance exercise tolerance and overall quality of life for patients with Parkinson's Disease.
How similar studies have performed: While the use of adaptive deep brain stimulation is a novel approach, similar studies have shown promise in managing Parkinson's Disease symptoms.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: Persons with PD who have a Medtronic DBS Sensight implant and a Percept IPG. \- Exclusion Criteria: Persons not meeting the above listed implant criteria Persons not meeting the age limit criteria Persons who are not able to complete the study exercise Persons not able to comprehend and consent to study participation.
Where this trial is running
Aurora, Colorado
- University of Colorado — Aurora, Colorado, United States (RECRUITING)
Study contacts
- Study coordinator: Pamela David Gerecht, PhD
- Email: pamela.davidgerecht@cuanschutz.edu
- Phone: 303-724-4134
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Parkinson Disease