Using acetaminophen before surgery to improve recovery and cognitive function
Effects of Acetaminophen Preemptive Analgesia on Anesthesia Recovery Time and Postoperative Cognitive Function in Patients Undergoing Gastrointestinal Tumor Surgery
This study tests if taking acetaminophen before gastrointestinal tumor surgery can help patients recover faster and think better after the operation.
Quick facts
| Phase | Phase1; Phase2 |
|---|---|
| Study type | Interventional |
| Enrollment | 100 (estimated) |
| Ages | 16 Years to 88 Years |
| Sex | All |
| Sponsor | Affiliated Hospital of Nantong University Academic / other |
| Locations | 1 site (Nantong, Jiangsu) |
| Trial ID | NCT06004687 on ClinicalTrials.gov |
What this trial studies
This study investigates the effects of preemptive analgesia using acetaminophen mannitol on patients undergoing gastrointestinal tumor surgery. It aims to determine how this intervention influences recovery time from anesthesia and cognitive function post-surgery. Patients will receive the treatment prior to surgery, and their recovery and cognitive status will be assessed at multiple intervals after the procedure. The goal is to provide insights into reducing postoperative cognitive dysfunction in this patient population.
Who should consider this trial
Good fit: Ideal candidates are patients scheduled for gastrointestinal tumor surgery with an ASA classification of Ⅲ or lower.
Not a fit: Patients with severe organ dysfunction, chronic pain, or those who have had adverse reactions to acetaminophen may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could lead to faster recovery times and improved cognitive outcomes for patients after gastrointestinal surgery.
How similar studies have performed: While the use of preemptive analgesia is a common practice, the specific application of acetaminophen mannitol for cognitive function in this context is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients undergoing gastrointestinal tumor surgery * American Society of Anesthesiologists（ASA）≤Ⅲ Exclusion Criteria: * History of severe adverse reactions to oral acetaminophen * Dysfunction of heart, liver, kidney and other important organs * History of chronic pain * Oral non-steroidal or opioid drugs * Patients who do not accept clinical trials
Where this trial is running
Nantong, Jiangsu
- Affiliated Hospital of nantong University — Nantong, Jiangsu, China (Recruiting)
Study contacts
- Study coordinator: Hongsheng Chen
- Email: chenhongsheng8@163.com
- Phone: +86 513 81160313
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.