Using a special PET scan to detect invasive fungal infections

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational pilot trial aims to evaluate the effectiveness of a gallium-siderophore tracer in identifying areas of invasive Aspergillus infection in patients. It will involve 10 participants who have been diagnosed with invasive fungal infections within the last two weeks. The study will assess the localized uptake of the tracer using a 68Ga-labelled TAFC PET/CT scan, while also monitoring the safety and tolerability of this imaging technique. The trial is conducted at a single center over a period of 12-24 months.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Patient has provided written informed consent
2. Aged 18 years or older at written informed consent
3. Within 2 weeks of proven or probable or possible invasive fungal infection (IFI) diagnosis as per EORTC criteria
4. Imaging consistent with invasive pulmonary aspergillosis on CT or FDG-PET/CT with lesions at least 8mm in diameter
5. Patient is willing and able to comply with the protocol for the duration of the study including scheduled visits such as follow up

Exclusion Criteria:

1. Women who are pregnant or lactating.
2. Iron infusion within one week prior to scan

Where it's running

• Peter MacCallum Cancer Centre
  Melbourne, Victoria, Australia Recruiting

Study contacts

• Study coordinator: Abby Douglas
• Email: Abby.Douglas@petermac.org
• Phone: 03 855 96136

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Low-dose Liposomal Amphotericin B for preventing fungal infections in adults with blood cancers and prolonged neutropenia

  This study tests whether giving a daily 50 mg dose of liposomal amphotericin B can help prevent invasive fungal infections in adults with blood cancers who have prolonged low white blood cell counts.

  Recruiting Haikou Affiliated Hospital of Central South University Xiangya School of Medicine · Hainan, Hainan · NCT07763054

• Low-dose liposomal amphotericin B to prevent invasive fungal infections in neutropenic children

  This study tests whether giving a fixed low dose of liposomal amphotericin B can prevent invasive fungal infections in children aged 3–17 who are severely neutropenic after hematopoietic stem cell transplantation or similar high-risk conditions.

  Recruiting Haikou Affiliated Hospital of Central South University Xiangya School of Medicine · Haikou, Hainan · NCT07725263

• Breath analysis to detect fungal infections in leukemia patients

  This study is testing if analyzing breath samples can help doctors detect fungal infections in leukemia patients who are at high risk due to their treatment.

  Recruiting University of Zurich · Zurich, Canton of Zurich · NCT06537726

• Evaluating the role of PET-CT in managing invasive fungal infections

  This study is testing if a special type of scan called PET-CT can help doctors better manage invasive fungal infections compared to regular imaging methods.

  Recruiting at 12 sites Puerta de Hierro University Hospital · Majadahonda, Madriid and 13 other locations · NCT05688592

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.