Using a special fluorescent probe to improve endoscopy for gastrointestinal issues
Official title: Study of Vascular Endothelial Growth Factor A Targeting NIR-II Fluorescence in the Endoscopy of Gastrointestinal Tract
Run by Institute of Automation, Chinese Academy of Sciences · NCT06430372 · Data updated 2026-11-12
This study is testing a new fluorescent probe during endoscopy to see if it can help doctors find abnormal tissues in the gastrointestinal tract more accurately.
Quick facts
| Phase | Phase 1 |
|---|---|
| Study type | Interventional |
| Ages | 18 Years to 75 Years |
| Sex | All |
| Enrollment | 30 (estimated) |
| Sponsor | Institute of Automation, Chinese Academy of Sciences Academic / other |
| Locations | 1 site (Beijing, Beijing Municipality) |
| Status | Recruiting |
| Started | July 20, 2023 |
| Main results expected | May 30, 2025 |
| Study ends | May 30, 2026 |
| Registry record updated | May 13, 2025 |
| Trial ID | NCT06430372 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include individuals with known or suspected gastrointestinal lesions who are scheduled for an endoscopy.
✕Probably not a fit
Patients with known allergies to ICG or those with significant organ dysfunction may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study investigates a novel approach to enhance the detection of abnormal tissues in the gastrointestinal tract during endoscopy using a VEGF-A targeting fluorescent probe and a NIR-II fluorescence endoscope. The main goals are to translate this advanced imaging technique into clinical practice, validate the effectiveness of the topical probe in adhering to abnormal tissues, and assess the safety of this method. Participants will be those scheduled for clinically-indicated endoscopies and will be monitored for potential follow-up. The study aims to provide a more accurate and effective way to identify gastrointestinal lesions.
Why it matters
Potential benefit: If successful, this approach could lead to earlier and more accurate detection of gastrointestinal cancers and other abnormalities.
How similar studies have gone: While this approach is innovative, similar studies using advanced imaging techniques have shown promise in improving detection rates in other areas of medicine.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Known or suspected gastrointestinal lesions. * Scheduled for a clinically-indicated endoscopy. * Mentally competent person, 18 years or older. * Approved to sign the informed consent. * Adequate potential for follow-up. Exclusion Criteria: * Subjects with known allergy or negative reaction to ICG or derivatives. * Undesirable function of heart, lung, kidney, or any other organs. * Enrolled in other trials in the past 3 months. * Pregnant or trying to conceive. * Unable to tolerate an endoscopy. * Medical or psychiatric conditions that compromise the patient's ability to give informed consent. * The researchers considered inappropriate to be included.
Where it's running
-
Lidan Fu
Beijing, Beijing Municipality, China Recruiting
Study contacts
- Study coordinator: Lidan Fu
- Email: fulidan2021@ia.ac.cn
- Phone: 17754927702
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.