Using a smell test to help diagnose Parkinson's disease in Vietnam
Validation of the Utility of the Vietnamese Smell Identification Test in Vietnamese Patients With Parkinson's Disease
This study is testing if a new smell test can help doctors better diagnose Parkinson's disease in people in Vietnam by comparing it to a standard smell test.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 218 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University Medical Center Ho Chi Minh City (UMC) Academic / other |
| Locations | 1 site (Ho Chi Minh) |
| Trial ID | NCT05837637 on ClinicalTrials.gov |
What this trial studies
This observational study aims to evaluate the effectiveness of the Vietnamese Smell Identification Test (VSIT) in diagnosing Parkinson's disease by comparing it with the widely used Brief Smell Identification Test (BSIT). Participants will undergo cognitive assessments and provide socio-demographic information, while those diagnosed with Parkinson's will be evaluated for their olfactory identification abilities. The study will analyze the sensitivity, specificity, and predictive values of both tests to determine their diagnostic capabilities. Additionally, it will explore factors associated with olfactory identification in patients with Parkinson's disease.
Who should consider this trial
Good fit: Ideal candidates include individuals aged 18 and older with a clinical diagnosis of Parkinson's disease and a Mini-Mental State Examination (MMSE) score above 24.
Not a fit: Patients with a history of head trauma, nasal surgery, other neurodegenerative diseases, or those currently experiencing upper respiratory infections may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance the diagnostic accuracy for Parkinson's disease, particularly in populations where traditional methods may be less effective.
How similar studies have performed: Previous studies have indicated that olfactory dysfunction is a common early symptom of Parkinson's disease, suggesting that similar approaches have shown promise in diagnosing the condition.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Aged 18 years and older * MMSE score \> 24 * Clinical diagnosis of Parkinson's disease (for patient group) Exclusion Criteria: * History of trauma to the head, history of nasal bone fracture, and history of nasal cosmetic surgery * Brain neoplasms * History of stroke, epilepsy * Secondary Parkinson's and Parkinson's Plus * Other neurodegenerative diseases, such as Alzheimer's * Mental disorders, such as schizophrenia, depression * Upper respiratory tract infections in the 2 weeks * Pregnancy * Exposure to medications relating to olfactory reduction, for instance, some particular antibiotics, antiepileptics, antithyroid or benzodiazepines * Having reported COVID-19 compatible smell symptomatology
Where this trial is running
Ho Chi Minh
- Ho Chi Minh University Medical Center — Ho Chi Minh, Vietnam (Recruiting)
Study contacts
- Principal investigator: Thi Huyen Thuong Dang — Ho Chi Minh University Medical Center
- Study coordinator: Thi Huyen Thuong Dang, Master
- Email: thuong.dth@umc.edu.vn
- Phone: +84907587738
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.