Using a Smart Checklist to Improve Pediatric Intubation Safety in ICUs
Official title: Smart Checklist Implementation for Pediatric Tracheal Intubations in the ICU- Multicenter Study
Run by Children's Hospital of Philadelphia · NCT06085326 · Data updated 2026-11-12
This study is testing a new digital checklist to see if it can make tracheal intubations safer for children in intensive care units.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | Any age to 19 Years |
| Sex | All |
| Enrollment | 3000 (estimated) |
| Sponsor | Children's Hospital of Philadelphia Academic / other |
| Locations | 6 sites (Little Rock, Arkansas and 5 other locations) |
| Status | Recruiting |
| Started | October 1, 2023 |
| Main results expected | June 30, 2028 |
| Study ends | September 30, 2028 |
| Registry record updated | October 22, 2026 |
| Trial ID | NCT06085326 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are critically ill pediatric patients who require tracheal intubation in participating PICUs.
✕Probably not a fit
Patients undergoing endotracheal tube exchanges will not benefit from this study as it involves a different procedure.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study aims to implement a digitized Smart Checklist tailored to patient-provider interactions to enhance the safety of tracheal intubations in pediatric intensive care units (PICUs). The checklist includes prompts based on patient characteristics, displays difficult airway information, and provides high-risk warnings using predictive analytics. Conducted across six hospitals, this stepped-wedge cluster randomized trial will evaluate the checklist's effectiveness in reducing adverse airway outcomes during intubation procedures. The study also seeks to understand the work systems and processes that influence the checklist's clinical impact.
Why it matters
Potential benefit: If successful, this intervention could significantly reduce the incidence of adverse airway outcomes in critically ill children undergoing intubation.
How similar studies have gone: Other studies have shown success with similar quality improvement interventions in healthcare settings, suggesting a promising approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: All patients intubated in the PICU at participating sites Exclusion Criteria: Endotracheal tube exchanges, as this represents a distinct procedure
Where it's running
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University of Arkansas
Little Rock, Arkansas, United States Recruiting -
Emory University
Atlanta, Georgia, United States Recruiting -
University of Nebraska Medical Center
Omaha, Nebraska, United States Recruiting -
Akron Children's Hospital
Akron, Ohio, United States Recruiting -
Hasbro Children's Hospital
Providence, Rhode Island, United States Recruiting -
University of Virginia
Charlottesville, Virginia, United States Recruiting
Study contacts
- Principal investigator: Akira Nishisaki, MD, MSCE — Children's Hospital of Philadelphia
- Study coordinator: Akira Nishisaki, MD, MSCE
- Email: nishisaki@chop.edu
- Phone: 215-590-1000
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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This study tests how the anesthetics propofol and ketamine affect heart stability in critically ill patients during intubation to see which one is safer.
-
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This study is testing whether a new device for securing breathing tubes works better than the usual method to help prevent complications for patients in intensive care.
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Comparing video and direct laryngoscopy for intubation by anesthesiology residents
This study tests whether using video laryngoscopy helps first-year anesthesiology residents do intubations more successfully and safely compared to the traditional direct method.
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Using ultrasound to confirm correct intubation in patients
This study tests if using ultrasound can help doctors make sure they are placing breathing tubes in the right spot during surgery to avoid complications.
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InfasurfAero™ for treating respiratory distress in preterm newborns
This study is testing a new device that delivers a treatment for breathing problems in preterm newborns to see if it helps them breathe better without needing a breathing tube.
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Improving safety of tracheal intubation in newborns
This study is testing a new safety plan for intubating newborns in NICUs to see if it can lower the risk of complications during the procedure.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.