Using a potassium‑competitive acid blocker after PCI to protect the stomach.

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is an observational target‑trial emulation comparing routine use of potassium‑competitive acid blockers (P‑CABs) versus guideline‑directed proton pump inhibitor (PPI) use for gastrointestinal protection in patients who underwent percutaneous coronary intervention (PCI) and remain on dual antiplatelet therapy (DAPT). The study uses real‑world clinical data from Samsung Medical Center to compare efficacy (GI bleeding prevention) and safety (including cardiovascular events) between the two approaches. Researchers will apply statistical methods to emulate a randomized trial and adjust for confounding factors such as baseline bleeding risk and concomitant medications. Outcomes will include rates of GI bleeding, major adverse cardiovascular events, and other safety endpoints during follow‑up.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients who underwent PCI
* Use of either clopidogrel, prasugrel, or ticagrelor in combination with aspirin
* No use of PCAB, PPI, or an H2-receptor within the past month

Exclusion Criteria:

* Patients with low GI bleeding risk are taken on PPI
* Patients with high GI bleeding risk do not take PPI

Where it's running

• Samsung Medical Center
  Seoul, South Korea Recruiting

Study contacts

• Principal investigator: KI HONG CHOI, MD, PhD — Samsung Medical Center
• Study coordinator: Ki Hong Choi, MD, PhD
• Email: cardiokh@gmail.com
• Phone: 82-2-3410-3419

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.