Using a portable VR headset to measure pupil reactions for diagnosing and monitoring head injury

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The study uses a portable virtual reality headset programmed to present brief, low-intensity chromatic light stimuli while the built-in camera records pupillary responses. Participants include combat-related mild to moderate TBI patients, age- and gender-matched soldiers with non-TBI trauma, and healthy adults. All participants undergo a full eye exam (including intraocular pressure, slit-lamp exam, visual acuity, and color vision) and VR Chromatic Pupilloperimetry testing, and TBI cases are characterized by positive blood biomarkers (GFAP/UCHL1) and/or acute head CT findings. The design is observational and compares pupil response patterns across groups to see if the VR pupillometry signatures correspond with TBI presence and severity.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Male and female subjects
2. Clear ocular media a

TBI group:

1. Combat-related mild to moderate TBI
2. Have either elevated TBI-associated blood biomarkers (Abbott Allinity I, GFAP/ UCHL1) and/or initial trauma head CT positive for acute intracranial trauma

Non-TBI Trauma group:

1\. Age- and gender-similar soldiers without TBI (defined as war-related injury who screen negative for TBI based on symptoms, blood, and/or head CT)

Exclusion Criteria:

1. Neuropsychiatric diseases
2. Any other neurodegenerative diseases
3. History of stroke, epilepsy, head trauma, or head tumors
4. Ocular disease or ocular surgery within the last six months

Where it's running

• Sheba Medical Center
  Tel HaShomer, Tel Aviv (Gosh Dan), Israel Recruiting

Study contacts

• Study coordinator: Lori Gueta
• Email: Lori.Gueta@sheba.health.gov.il
• Phone: +972527485888

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.