Using a patient's own tooth material plus PRF or albumin-PRF to preserve the extraction socket
Official title: Comparison of Autogenous Dentin Graft With Albumin Platelet Rich Fibrin Versus Autogenous Dentin Graft With Platelet Rich Fibrin in Alveolar Socket Preservation: A Randomized Controlled Clinical Trial.
Run by Kafrelsheikh University · NCT06757218 · Data updated 2026-11-12
This test tries whether filling a lower back tooth extraction socket with the patient's own dentin plus either standard PRF or albumin-enhanced PRF better preserves jaw bone in healthy adults aged 18–60.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 60 Years |
| Sex | All |
| Enrollment | 60 (estimated) |
| Sponsor | Kafrelsheikh University Academic / other |
| Locations | 1 site (Kafr ash Shaykh, Kafrelsheikh) |
| Status | Recruiting |
| Started | June 1, 2025 |
| Main results expected | June 30, 2026 |
| Study ends | August 30, 2026 |
| Registry record updated | July 10, 2025 |
| Trial ID | NCT06757218 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Healthy adults 18–60 with a non-restorable posterior mandibular tooth scheduled for extraction, without systemic disease, not pregnant or lactating, non-smokers, and with good oral hygiene are ideal candidates.
✕Probably not a fit
Patients with systemic illnesses, smokers, pregnant or lactating individuals, those with bone diseases or poor oral hygiene, or those needing anterior tooth treatment are unlikely to benefit from this protocol.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Participants are randomly assigned to one of three groups: empty socket (spontaneous healing), autogenous dentin graft with standard platelet-rich fibrin (PRF) block, or autogenous dentin graft with albumin-PRF (Alb-PRF) block, with 20 sockets per group. The removed tooth is cleaned, ground to 300–1200 μm particles, demineralized, rinsed, and dried to make the autogenous dentin graft, while PRF is prepared from a 10 ml blood draw and Alb-PRF is formed by combining L-PRF with albumin to create a stable membrane. Outcomes focus on post-extraction socket changes and bone preservation that affect future implant or prosthetic planning, especially within the early healing window when most ridge loss occurs. Procedures and follow-up visits are performed at the single site with standardized surgical and graft preparation protocols.
Why it matters
Potential benefit: If successful, this approach could reduce bone loss after extraction, making future implant placement easier and possibly avoiding additional grafting.
How similar studies have gone: Previous reports indicate autogenous dentin grafts and PRF can support socket healing, while albumin-enriched PRF is a newer technique with limited but encouraging early data.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Medically free patients. * Adult patients above 18 Years to 60 Years. * Non-restorable tooth indicated for extraction. * Posterior mandibular teeth. * Inactive infection related to the tooth. * Cooperative patients. Exclusion Criteria: * Presence of any systemic disease that could influence the outcome of the therapy. * Presence of any risk factor (smoker, pregnant and lactating patients). * Patients with bone diseases. * Patients with poor oral hygiene.
Where it's running
-
Kaferelsheikh University
Kafr ash Shaykh, Kafrelsheikh, Egypt Recruiting
Study contacts
- Study coordinator: Muath Atif Hassan
- Email: muath_01pg@den.kfs.edu.eg
- Phone: +201507571780
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Thymoquinone 0.2% Gel to Protect Bone After Tooth Extraction
A gel with 0.2% thymoquinone is tested to see if it helps keep bone density and width after pulling a back upper tooth in adults.
-
Comparing two bone grafts to preserve the socket after tooth extraction
This test will compare an allograft and a bovine xenograft to see which better preserves jaw bone and gum shape after tooth extraction in healthy adults aged 21–50.
-
Preserving the jawbone after a tooth extraction using hyaluronic acid and polynucleotides
This trial will test whether filling an extraction socket with a bovine bone graft plus a polynucleotide-rich hyaluronic acid gel helps preserve the jawbone and supports implant placement in adults needing a single tooth extraction.
-
Effects of Vitamin K2 on Bone Healing After Tooth Extraction
This study is testing whether using vitamin K2 during tooth extraction can help improve bone healing compared to not using it.
-
Evaluating the effects of vitamin C on bone preservation after tooth extraction
This study is testing if adding vitamin C to a bone graft after tooth extraction can help preserve bone better than just using the graft alone.
-
Effect of four post-extraction socket approaches on preserving the ridge after tooth removal
This study tests four ways to care for an extraction socket to see which best preserves the jawbone and gum after tooth removal for future implants.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.