Using a patient's own tooth material plus PRF or albumin-PRF to preserve the extraction socket
Comparison of Autogenous Dentin Graft With Albumin Platelet Rich Fibrin Versus Autogenous Dentin Graft With Platelet Rich Fibrin in Alveolar Socket Preservation: A Randomized Controlled Clinical Trial.
This test tries whether filling a lower back tooth extraction socket with the patient's own dentin plus either standard PRF or albumin-enhanced PRF better preserves jaw bone in healthy adults aged 18–60.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 60 (estimated) |
| Ages | 18 Years to 60 Years |
| Sex | All |
| Sponsor | Kafrelsheikh University Academic / other |
| Locations | 1 site (Kafr ash Shaykh, Kafrelsheikh) |
| Trial ID | NCT06757218 on ClinicalTrials.gov |
What this trial studies
Participants are randomly assigned to one of three groups: empty socket (spontaneous healing), autogenous dentin graft with standard platelet-rich fibrin (PRF) block, or autogenous dentin graft with albumin-PRF (Alb-PRF) block, with 20 sockets per group. The removed tooth is cleaned, ground to 300–1200 μm particles, demineralized, rinsed, and dried to make the autogenous dentin graft, while PRF is prepared from a 10 ml blood draw and Alb-PRF is formed by combining L-PRF with albumin to create a stable membrane. Outcomes focus on post-extraction socket changes and bone preservation that affect future implant or prosthetic planning, especially within the early healing window when most ridge loss occurs. Procedures and follow-up visits are performed at the single site with standardized surgical and graft preparation protocols.
Who should consider this trial
Good fit: Healthy adults 18–60 with a non-restorable posterior mandibular tooth scheduled for extraction, without systemic disease, not pregnant or lactating, non-smokers, and with good oral hygiene are ideal candidates.
Not a fit: Patients with systemic illnesses, smokers, pregnant or lactating individuals, those with bone diseases or poor oral hygiene, or those needing anterior tooth treatment are unlikely to benefit from this protocol.
Why it matters
Potential benefit: If successful, this approach could reduce bone loss after extraction, making future implant placement easier and possibly avoiding additional grafting.
How similar studies have performed: Previous reports indicate autogenous dentin grafts and PRF can support socket healing, while albumin-enriched PRF is a newer technique with limited but encouraging early data.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Medically free patients. * Adult patients above 18 Years to 60 Years. * Non-restorable tooth indicated for extraction. * Posterior mandibular teeth. * Inactive infection related to the tooth. * Cooperative patients. Exclusion Criteria: * Presence of any systemic disease that could influence the outcome of the therapy. * Presence of any risk factor (smoker, pregnant and lactating patients). * Patients with bone diseases. * Patients with poor oral hygiene.
Where this trial is running
Kafr ash Shaykh, Kafrelsheikh
- Kaferelsheikh University — Kafr ash Shaykh, Kafrelsheikh, Egypt (Recruiting)
Study contacts
- Study coordinator: Muath Atif Hassan
- Email: muath_01pg@den.kfs.edu.eg
- Phone: +201507571780
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.