Using a laser to reduce post-inflammatory hyperpigmentation
Official title: Efficacy and Safety of the Fractionated 1927-nm Non Ablative Thulium Laser in Treating Post Inflammatory Hyperpigmentation in Skin Phototypes IV-VI
Run by Henry Ford Health System · NCT06149780 · Data updated 2026-11-12
This study is testing whether a special laser treatment can help reduce dark spots on the skin caused by inflammation in people with darker skin types.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 15 (estimated) |
| Sponsor | Henry Ford Health System Academic / other |
| Locations | 1 site (Detroit, Michigan) |
| Status | Recruiting |
| Started | November 15, 2023 |
| Main results expected | August 1, 2026 |
| Study ends | August 30, 2026 |
| Registry record updated | June 25, 2025 |
| Trial ID | NCT06149780 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults aged 18 and older with skin phototypes IV-VI who have not used certain medications for pigmentary abnormalities prior to the study.
✕Probably not a fit
Patients with existing skin conditions that obscure study results, such as dyspigmentation or tattoos, will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study investigates the effectiveness of a fractionated 1927-nm non-ablative thulium laser in reducing post-inflammatory hyperpigmentation (PIH) in patients with skin types IV-VI. Participants will undergo three monthly laser treatment sessions, and the study will also evaluate the efficacy of a topical steroid ointment in managing PIH. Assessments will include visual examinations, photography, and colorimetry, with optional biopsies taken at various time points to analyze histological and molecular changes. The study aims to provide a validated model for understanding and treating PIH.
Why it matters
Potential benefit: If successful, this treatment could significantly improve the appearance of skin affected by post-inflammatory hyperpigmentation.
How similar studies have gone: While the specific approach of using a 1927-nm laser for PIH is relatively novel, similar laser treatments have shown promise in other studies.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patient age 18 and older * Patient with skin phototypes IV-VI * Patient able to understand requirements of the study and risks involved * Patient able to sign a consent form * Patient to have discontinued all oral medications used to treat pigmentary abnormalities and all topical medications, except for sunscreen, used to treat pigmentary abnormalities on the buttocks one month prior to treatment Exclusion Criteria: * A patient who has skin dyspigmentation, birth marks, tattoos, or other skin findings at baseline on either buttock that may obscure study results * A patient who is lactating, pregnant, or planning to become pregnant
Where it's running
-
Henry Ford Medical Center
Detroit, Michigan, United States Recruiting
Study contacts
- Study coordinator: Fanar Razoky, Bachelors
- Email: frazoky1@hfhs.org
- Phone: 313-694-1923
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.