Using a device to remove carbon dioxide to reduce lung injury in ARDS patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study investigates the use of extracorporeal carbon dioxide removal (ECCO2R) devices in patients with acute respiratory distress syndrome (ARDS) who are on mechanical ventilation. The study aims to assess whether these devices can effectively reduce hypercapnia and hypercapnic acidosis, which are associated with increased mortality in ventilated patients. By minimizing these conditions, the study seeks to demonstrate a potential reduction in ventilator-induced lung injury. The study will include adult patients diagnosed with ARDS who meet specific respiratory criteria.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Adult patients (18 years or older) with diagnosis of ARDS as per Berlin Definition21.

Driving pressure (ΔP) \> 14 and/or Plateau \>/= 25 (ΔP is calculated using as plateau pressure minus positive end-expiratory pressure)20 Respiratory rate \> 20 breaths per minute pH \< 7.25 and PaCO2 \>45

Exclusion Criteria:

ARDS lasting more than 72 hours at the time of inclusion High pressure (Plateau pressure \>30 cm H2O) or high FiO2 (\>0·8) ventilation for more than 168 h (7 days); Life threatening hemodynamic instability as defined by ongoing arrhythmias that is not responsive to treatment Contraindication to limited anticoagulation Treatment limitation including not for resuscitation and not for reintubation Patients with potentially irreversible respiratory failure caused by conditions such as pulmonary fibrosis.

Where it's running

• Frankston Hospital
  Frankston, Victoria, Australia Recruiting

Study contacts

• Principal investigator: RAVINDRANATH TIRUVOIPATI, PhD — Peninsula Heatlh
• Study coordinator: RAVINDRANATH TIRUVOIPATI, PhD
• Email: Rtiruvoipati@phcn.vic.gov.au
• Phone: +61431279347

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.