Using a collagen matrix to treat gum recession

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study evaluates the effectiveness of a xenogenic collagen matrix (XCM) compared to an autologous connective tissue graft (CTG) for treating multiple adjacent gingival recessions using a multiple coronally advanced flap technique (mCAF). The primary focus is on recession reduction, while secondary outcomes include changes in keratinized tissue width, probing pocket depth, and patient-reported outcomes such as pain and swelling. Participants will be monitored at 6 months and 1 year to assess the results of both treatment methods.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* At least 18 years old and able to sign informed consent
* At least 2 adjacent teeth with RT1 and/or RT2 gingival recessions without interproximal exposure of the CEJ (interdental gingival recession), at least one with a depth of ≥2mm with indication for root coverage treatment
* A minimum of 4 adjacent teeth (including the ones to be treated) in the region of interest
* Available to attend study related procedures (including follow-up visits)

Exclusion Criteria:

* Systemic diseases/medications which could influence the outcome of the therapy (e.g., uncontrolled diabetes mellitus);
* Current smokers (self-reported, any type of smoking), users of chewing tobacco, and drug/alcohol abusers;
* Pregnant or nursing women;
* History of previous periodontal surgery (mucogingival or other) on the teeth to be included;
* Furcation involvement in the teeth to be included;
* Presence of severe tooth malposition, rotation or clinically significant extrusion in the teeth to be treated;
* Presence of fixed or removable prosthesis in the area to be treated

Where it's running

• CIR Dental School
  Turin, Italy Recruiting

Study contacts

• Study coordinator: Mario Aimetti, MD
• Email: mario.aimetti@unito.it
• Phone: 0116331546

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Palatal Wound Healing After Free Gingival Graft in Diabetic Patients

  This study tests palatal wound healing after a free gingival graft in adults with and without diabetes to see if diabetes affects healing and what factors are linked to outcomes.

  Recruiting University of Kentucky · Lexington, Kentucky · NCT07500935

• Oral Mucosa Healing After Gum Recession Treatment in Diabetic People

  This study tests how gingival recession treatment heals in people with diabetes compared with people without diabetes.

  Recruiting University of Kentucky · Lexington, Kentucky · NCT07470281

• CAF versus TCAF with connective tissue grafts for multiple maxillary gum recessions

  This comparison will test whether coronally advanced flap (CAF) or tunneled coronally advanced flap (TCAF), each combined with a connective tissue graft, provides better root coverage for adults with multiple gum recessions in the upper jaw.

  Recruiting University Hospital, Ghent · Ghent, Oost-Vlaanderen · NCT07158528

• Using NovoMatrix for treating gum recession

  This study is testing whether a new treatment called NovoMatrix can help people with gum recession improve their gum health and appearance after surgery.

  Recruiting Semmelweis University · Budapest · NCT06409468

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.