Using a collagen matrix to prevent bone loss during dental implant placement in the front teeth area.

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial aims to compare the effectiveness of a porcine collagen matrix versus traditional autogenous connective tissue grafts in preventing buccal bone resorption during single dental implant placement in the aesthetic zone. The study will involve 36 generally healthy adult participants who require an implant in the upper aesthetic zone and will assess clinical and radiographic outcomes six months post-operation. The trial is designed as a prospective, randomized controlled study, focusing on both histological assessments and patient-reported outcomes to evaluate the success of the interventions.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Generally healthy adult patients.
2. 18 years or older.
3. Need for replacement of single implant in the upper aesthetic zone (second premolar to second premolar)
4. Ridge width (bucco-lingual) no greater than 6 mm at its narrowest point.
5. Minimum 2mm of attached gingiva.
6. Ability to comply with the study related procedures such as exercising good oral hygiene and attending all follow-up examinations.
7. Ability to fully understand the nature of the proposed surgery and ability to sign the informed consent form

Exclusion Criteria:

1. Poor oral hygiene (FMPS \< 20%, FMBS \< 15%) and poor motivation
2. Heavy smokers (\>10 cigarettes per day)
3. Need for bone augmentation
4. Untreated periodontitis
5. General contraindications for dental and/or surgical treatment
6. History of malignancy, radiotherapy, or chemotherapy for malignancy within the past 5 years
7. Women of child bearing age, not using a standard accepted method for contraception
8. Pregnancy or breast feeding
9. Previous and concurrent medication affecting mucosal healing in general (e.g. steroids, large doses of anti-inflammatory drugs
10. Disease affecting connective tissue metabolism (e.g. collagenases)
11. Allergy to collagen

Where it's running

• Department of Preventive Dentistry, Periodontology & Implant Biology, School of Dentistry, Aristotle University
  Thessaloniki, Thessaloniki, Greece Recruiting

Study contacts

• Study coordinator: Ioannis Vouros, DDS, Ph.D
• Email: iovouros@dent.auth.gr
• Phone: +302310999597

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.