Using a CD38 antibody with corticosteroids to treat acquired hemophilia A

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study evaluates the effectiveness of a combination treatment using the CD38 monoclonal antibody Daratumumab and corticosteroids for patients with acquired hemophilia A (AHA). It is a prospective, single-arm, multi-center pilot trial that aims to assess the time of response, sustained remission rates, and relapse rates associated with this treatment. Additionally, the study will monitor the safety profile of Daratumumab in this patient population. Participants will receive the treatment and be closely monitored throughout the trial.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients must meet all enrollment criteria before they can be enrolled:

Diagnosed as AHA; Women are postmenopausal women or women of childbearing age with strict contraception; Patients with good compliance

Exclusion Criteria:

* Patients with any of the following items cannot be enrolled in this study:

Congenital hemophilia with inhibitor; Pregnant and lactating women; Who are positive for hepatitis B surface antigen, hepatitis C antibody, HIV antibody (Ⅰ + Ⅱ) and syphilis antibody; Patients with poor compliance; Who cannot use contraception during the trial; Researchers believe that it is not appropriate for patients to participate in any other condition of this trial; Four weeks before entering the group, the patients received immunosuppressive therapy and the inhibitor showed a progressive decreasing trend (the change was less than 50%).

Acquired von Willebrand disease

Where it's running

• Chinese Academy of Medical Science and Blood Disease Hospital
  Tianjin, China Recruiting

Study contacts

• Principal investigator: Lei Zhang — Chinese Academy of Medical Science and Blood Disease Hospital
• Study coordinator: Wei Liu
• Email: liuwei1@ihcams.ac.cn
• Phone: +8613820261971

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.