Using a carbohydrate-rich diet to treat acute intermittent porphyria
Official title: Clinical Research on Acute Intermittent Porphyria and the Use of Carbohydrate-Rich Diet as a Treatment
Run by Nordlandssykehuset HF · NCT06273644 · Data updated 2026-11-12
This study is testing whether a high-carbohydrate diet can help people with acute intermittent porphyria feel better by looking at changes in their symptoms and health markers.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 50 (estimated) |
| Sponsor | Nordlandssykehuset HF Academic / other |
| Locations | 3 sites (Bodø, Nordland and 2 other locations) |
| Status | Recruiting |
| Started | January 27, 2024 |
| Main results expected | October 31, 2027 |
| Study ends | December 31, 2037 |
| Registry record updated | March 27, 2026 |
| Trial ID | NCT06273644 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are adults diagnosed with acute intermittent porphyria.
✕Probably not a fit
Patients who do not have a diagnosis of acute intermittent porphyria or those with diabetes may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This clinical trial investigates the effects of a carbohydrate-rich diet on patients with acute intermittent porphyria (AIP). Participants will follow two different diet plans over an 8-week period, alternating between high and moderate carbohydrate intake. The study aims to assess changes in symptoms, glucose levels, insulin, cytokines, amino acids, and gut microbiota, as well as mitochondrial activity and potential genetic mutations. The research will be conducted at Nordland Hospital and the University of Oslo, involving 50 participants diagnosed with AIP.
Why it matters
Potential benefit: If successful, this study could provide a novel dietary treatment option that alleviates symptoms and improves health outcomes for patients with acute intermittent porphyria.
How similar studies have gone: While dietary interventions have been explored in other conditions, this specific approach for acute intermittent porphyria is novel and has not been extensively tested.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Diagnosis of AIP Exclusion Criteria: * Not having diagnosis of AIP * Undergoing treatment as part of other clinical research on AIP * Pregnancy * Diabetes * Below 18 years of age
Where it's running
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Nordland Hospital Trust
Bodø, Nordland, Norway Recruiting -
Studieenheten, Akademiskt Specialistcentrum, Stockholm läns sjukvårdsområde, Region Stockholm
Stockholm, Sweden Recruiting -
Norrland University Hospital
Umeå, Sweden Recruiting
Study contacts
- Principal investigator: Elin Storjord, MD PhD — Nordlandssykehuset HF
- Study coordinator: Elin Storjord, MD PhD
- Email: elin.storjord@nordlandssykehuset.no
- Phone: 97072484
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Identifying genes that affect Acute Intermittent Porphyria
This study is trying to find out which genes might make people more likely to have attacks of Acute Intermittent Porphyria or help protect them from it, and it's for anyone aged 12 and older who has symptoms or is related to someone with the condition.
-
Registry for patients with Acute Hepatic Porphyria
This study is creating a registry to track the experiences and treatment results of people with Acute Hepatic Porphyria to see how well givosiran and other approved therapies work in real life.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.