Using a capsule system to detect Barrett's Esophagus
Official title: Use of a Detachable String Capsule for Evaluation of Barrett's Esophagus
Run by Mayo Clinic · NCT06748911 · Data updated 2026-11-12
This study is testing a new capsule system to see if it can help find Barrett's Esophagus in adults who have had an endoscopy recently.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 22 Years and up |
| Sex | All |
| Enrollment | 57 (estimated) |
| Sponsor | Mayo Clinic Academic / other |
| Locations | 1 site (Jacksonville, Florida) |
| Status | Recruiting |
| Started | February 20, 2025 |
| Main results expected | September 30, 2026 |
| Study ends | September 30, 2026 |
| Registry record updated | August 19, 2026 |
| Trial ID | NCT06748911 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults aged 22 and older who have had an endoscopy within the last year and meet specific criteria related to Barrett's Esophagus or chronic GERD.
✕Probably not a fit
Patients with active esophageal tumors, significant dysphagia, or those who have had certain types of esophageal surgery may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study evaluates the effectiveness of the NaviCam Detachable String Capsule, a non-invasive capsule system designed to provide optimal viewing angles of the esophagus for the detection of Barrett's Esophagus. Participants will include adults who have undergone an endoscopy within the past year, with specific inclusion criteria for those with Barrett's Esophagus or chronic GERD. The study aims to improve the detection methods for this condition, potentially leading to better patient outcomes.
Why it matters
Potential benefit: If successful, this approach could enhance the early detection of Barrett's Esophagus, leading to timely interventions and improved patient management.
How similar studies have gone: While this approach is innovative, similar studies have shown promise in improving detection methods for esophageal conditions.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria * Adults greater than or equal to 22 years of age with or without Barrett's Esophagus * All Patients: o Have had an endoscopy within 1 year of baseline enrollment * Patients with Barrett's Esophagus: * Presence of at least 1cm of salmon colored mucosa with corresponding biopsies showing intestinal metaplasia who are treatment naïve and undergoing surveillance Or * Chronic Gastro Esophageal Reflux Disease (GERD) patients with at least 3 additional risk factors that meet Barrett's Esophagus screening criteria per latest clinical guidelines Exclusion Criteria * Inability to comprehend or read the consent form * Have an oropharynx, esophageal, or gastro-esophageal tumor * Ongoing symptoms of dysphagia * Presence of active clinically significant stricture * History of stricture requiring dilation * Presence of pacemaker or implanted cardiac defibrillator * History of esophageal surgery with the exception of fundoplication * Pregnancy * History of surgery or obstructive process of the small bowel * BMI \> 38
Where it's running
-
Mayo Clinic in Florida
Jacksonville, Florida, United States Recruiting
Study contacts
- Principal investigator: Swathi Eluri — Mayo Clinic
- Study coordinator: Stephanie McNew
- Email: McNew.Stephanie@mayo.edu
- Phone: 904-953-5080
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Using tissue, brush, and blood tests to improve cancer risk prediction and quality of life tracking in Barrett's Esophagus
This will try extra biopsies, esophageal brushings, blood tests, and short questionnaires to see if they can better predict cancer risk and track quality of life for adults with Barrett's Esophagus who are being evaluated for possible early cancer.
-
Investigating the best biopsy methods for Barrett's Esophagus
This study is testing different biopsy methods to see which one works best for finding early signs of Barrett's Esophagus in patients, especially in Asian populations.
-
Testing a new imaging capsule for Barrett's Esophagus
This study is testing a new imaging capsule to see if it can safely and easily take pictures of the esophagus in both healthy people and those with Barrett's Esophagus.
-
Treatment options for Barrett's Esophagus and related cancer
This study is looking at how well different treatments work for people with Barrett's esophagus and esophageal cancer to help improve their health and quality of life.
-
Observing Barrett's Esophagus with Dysplasia and Early Cancer
This study looks at how patients with Barrett's esophagus, especially those with serious changes or early cancer, are managed over time to see how their condition progresses and how well treatments work.
-
Project to improve detection of Barrett's Esophagus and related neoplasia
This study is testing new ways to better detect Barrett's esophagus and early signs of cancer to help improve care for patients with this condition.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.