Using a cap on the endoscope to find and treat upper GI bleeding
Official title: Is Cap Assisted Endoscopy Useful in Acute Upper Gastrointestinal Bleeding ?
Run by Centre Hospitalier Universitaire, Amiens · NCT07268365 · Data updated 2026-11-12
This trial tests whether adding a small clear cap to the tip of the endoscope helps doctors find and stop bleeding in adults with suspected acute upper gastrointestinal bleeding.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 72 (estimated) |
| Sponsor | Centre Hospitalier Universitaire, Amiens Academic / other |
| Locations | 1 site (Amiens, Picardie) |
| Status | Recruiting |
| Started | October 16, 2025 |
| Main results expected | October 2026 |
| Study ends | November 2026 |
| Registry record updated | December 5, 2025 |
| Trial ID | NCT07268365 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults over 18 with suspected upper GI bleeding (melena or hematemesis), a Glasgow-Blatchford score >8, presenting to and able to follow up at Amiens University Hospital, and with a gastric or duodenal ulcer requiring endoscopic hemostasis (Forrest Ia–IIb).
✕Probably not a fit
Patients with portal hypertension, known liver failure, variceal bleeding, lesions beyond the second portion of the duodenum, bleeding from esophagitis, or angiodysplasias are excluded and unlikely to benefit from this cap-assisted approach.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Adults presenting with melena or hematemesis and a high Glasgow-Blatchford score at Amiens University Hospital will undergo upper endoscopy using a cap attached to the scope to improve visualization of hidden mucosal areas. The cap is intended to expose blind spots behind folds and stabilize the scope to facilitate endoscopic hemostasis of gastric or duodenal ulcers (Forrest Ia–IIb). Outcomes will include identification rate of the bleeding source, hemostasis success, procedure time, and need for repeat interventions, with follow-up at the same center. This approach builds on cap-assisted techniques used in colonoscopy and limited case reports in upper GI bleeding but has not been tested systematically in larger cohorts.
Why it matters
Potential benefit: If successful, cap-assisted endoscopy could lead to faster identification and control of bleeding, fewer repeat procedures, and lower complication rates and costs.
How similar studies have gone: Cap-assisted endoscopy has improved detection in colonoscopy and a small four-case series suggested benefit in upper GI bleeding, but no larger trials have assessed systematic use in this setting.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patient \> 18 years old * Upper GI bleeding suspected in presence of melena or hematemesis * Glasgow Blatchford score \> 8 * Upper gastroscopy at Amiens University Hospital * Follow-up at Amiens university hospital * Presence of gastric or duodenal ulcer requiring endoscopic hemostasis (FORREST Ia, Ib, IIa, IIb) * No opposition to the study * No guardianship or curators Exclusion Criteria: * Patient with clinical suspicion of portal hypertension * Known liver failure * Patient with digestive hemorrhage related to a lesion located beyond the 2nd duodenum * Patient with digestive hemorrhage related to a varicose lesion (esophageal or gastric varices) * Patient with bleeding associated with esophagitis * Patient with bleeding associated with angiodysplasias
Where it's running
-
Centre Hospitalier Universitaire d'Amiens
Amiens, Picardie, France Recruiting
Study contacts
- Study coordinator: Clara YZET, MD
- Email: yzet.clara@chu-amiens.fr
- Phone: 33+3 22 08 88 50
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.