Using a botanical agent to inhibit oral cancer growth

Inhibition of Oral Tumorigenesis by Antitumor B

This study is testing a herbal treatment made from Chinese herbs to see if it can slow down the growth of oral cancer in patients before they have surgery.

Quick facts

• Phase: Early Phase 1
• Study type: Interventional
• Enrollment: 14 (estimated)
• Ages: 18 Years and up
• Sex: All
• Sponsor: Medical College of Wisconsin (Academic / other)
• Drugs / interventions: chemotherapy, radiation
• Locations: 1 site (Milwaukee, Wisconsin)
• Trial ID: NCT04278989 on ClinicalTrials.gov

What this trial studies

This study investigates the effects of Anti-tumor B, a botanical agent made from six Chinese herbs, on patients diagnosed with squamous cell cancer of the oral cavity. Participants will take four 300 mg pills three times daily for a period of seven to 28 days, depending on their surgery schedule. The goal is to assess the agent's ability to inhibit tumor growth before surgical intervention. Histological confirmation of the cancer diagnosis is required to continue participation in the study.

Who should consider this trial

Good fit: Ideal candidates are patients with a new diagnosis of clinical stage II-IVA squamous cell cancer of the oral cavity who are scheduled for surgical resection.

Not a fit: Patients whose confirmatory biopsy does not demonstrate invasive carcinoma will not benefit from this study.

Why it matters

Potential benefit: If successful, this treatment could provide a novel approach to inhibit the progression of oral squamous cell cancer prior to surgery.

How similar studies have performed: While the use of botanical agents in cancer treatment is an emerging field, this specific approach has not been widely tested, making it a novel investigation.

Eligibility criteria

Inclusion Criteria:

1. Voluntary written consent must be given before performance of any study-related procedure not part of standard medical care, with the understanding that consent may be withdrawn by the subject at any time without prejudice to future medical care.
2. In the event that the diagnosis of squamous cell cancer is made by an outside pathologist, hence not verified, the patient can start study agent administration but histological confirmation of squamous cell cancer (SCC) of the oral cavity (or histologic variants of SCC) by the pathologist must happen within seven days of registration in order to continue protocol therapy. Note: patients whose confirmatory biopsy fails to demonstrate invasive carcinoma will be excluded from continued participation in the study and considered a screen failure.
3. Clinical stage II-IVA (as defined by the American Joint Committee on Cancer (AJCC), 8th Edition), and amenable to surgical resection.
4. New diagnosis of oral SCC, new second primary, or recurrent oral SCC following a minimum remission of six months following previous definite surgery.
5. History and physical examination by an otolaryngologist and medical oncologist within 14 calendar days of study registration.
6. Zubrod/ECOG Performance status \< 2.
7. Age ≥ 18 years.
8. Complete Blood Count (CBC)/differential obtained within 14 calendar days prior to registration, with adequate bone marrow function defined as follows:

   * Absolute neutrophil count (ANC) ≥ 1,500 cells/mm\^3;
   * Platelets ≥ 100,000 cells/mm\^3;
   * Hemoglobin ≥ 8.0 g/dl (Note: The use of transfusion or other intervention to achieve Hgb ≥ 8.0 g/dl is acceptable).
9. Adequate renal and hepatic function within 14 calendar days prior to registration, defined as follows:

   * Serum creatinine \< 1.5 mg/dl or creatinine clearance (CCr) ≥ 50 ml/min within 14 calendar days prior to registration, determined by 24-hour collection or estimated by Cockcroft-Gault formula:
   * CCr male = \[(140 - age) x (wt in kg)\]
   * \[(Serum Cr mg/dl) x (72)\]
   * CCr female = 0.85 x (CrCl male)
10. Total bilirubin \< 2 x the institutional upper limit of normal (ULN);
11. Aspartate aminotransferase (AST) or alanine aminotransferase (ALT) ≤ 3 x the institutional ULN;
12. Magnesium, calcium, glucose, potassium, and sodium within 14 calendar days prior to registration, with the following required parameters:

    * Magnesium: \> 0.9 mg/dl or \< 3 mg/dl;
    * Calcium: \> 7 mg/dl or \< 12.5 mg/dl;
    * Glucose: \> 40 mg/dl or \< 250 mg/dl;
    * Potassium: \> 3 mmol/L or \< 6 mmol/L;
    * Sodium: \> 130 mmol/L or \< 155 mmol/L.
13. Eastern Cooperative Oncology Group (ECOG) performance status of 0 to 2.
14. Female subjects must meet one of the following:

    * Postmenopausal for at least one year before enrollment, OR
    * Surgically sterile (i.e., undergone a hysterectomy or bilateral oophorectomy), OR
    * If subject is of childbearing potential (defined as not satisfying either of the above two criteria), agrees to practice two acceptable methods of contraception (combination methods require use of two of the following: diaphragm with spermicide, cervical cap with spermicide, contraceptive sponge, male or female condom, hormonal contraceptive) from the time of signing of the informed consent form through 21days after the last dose of study agent, OR
    * Agrees to practice true abstinence when this is in line with the preferred and usual lifestyle of the subject. (Periodic abstinence \[e.g., calendar, ovulation, symptothermal, postovulation methods\] and withdrawal are not acceptable contraception methods.)
15. Male subjects, even if surgically sterilized (i.e., status postvasectomy), must agree to one of the following:

    * Practice effective barrier contraception during the entire study period and through 60 calendar days after the last dose of study agent, OR
    * Agree to practice true abstinence when this is in line with the preferred and usual lifestyle of the subject. (Periodic abstinence \[e.g., calendar, ovulation, symptothermal, postovulation methods\] and withdrawal are not acceptable methods of contraception.)
16. Enrollment on an interventional postoperative study is allowed if study agents do not overlap.
17. Gastric tube drug administration is permissible.

Exclusion Criteria:

1. Pregnant or lactating women are ineligible due to unforeseeable risks to embryo or fetus.
2. Concurrent use of any medicinal botanical, natural, or other herbal compounds.
3. Planned subtotal or debulking surgery is not permissible.
4. Prior systemic chemotherapy for oral SCC; note that prior chemotherapy for a different cancer is allowable.
5. Prior radiotherapy for oral SCC is permissible if disease free for one year since prior oral cancer treatment and free of significant late radiation effects.
6. Severe active comorbidity, such as uncontrolled cardiac disease, infection, and severe chronic obstructive pulmonary disease (COPD).

Where this trial is running

Milwaukee, Wisconsin

• Froedtert Hospital & the Medical College of Wisconsin — Milwaukee, Wisconsin, United States (Recruiting)

Study contacts

• Principal investigator: Stuart J Wong, MD — Medical College of Wisconsin
• Study coordinator: Medical College of Wisconsin Cancer Center Clinical Trials Office

Conditions Squamous Cell Cancer of the Oral Cavity