Using 7 Tesla MRI to Diagnose Post-Concussion Syndrome in Mild Traumatic Brain Injury Patients
Interest of the 7 Tesla MRI in the Diagnosis of Post-concussion Syndromes Among Patients With Mild Traumatic Brain Injury
This study is testing if a special type of MRI can help doctors find hidden brain injuries in people with mild head trauma who are experiencing ongoing concussion symptoms.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 100 (estimated) |
| Ages | 20 Years to 72 Years |
| Sex | All |
| Sponsor | Poitiers University Hospital Academic / other |
| Locations | 1 site (Poitiers) |
| Trial ID | NCT04982562 on ClinicalTrials.gov |
What this trial studies
This study aims to evaluate the effectiveness of 7 Tesla MRI in detecting diffuse axonal lesions in patients who have experienced mild traumatic brain injury and are presenting with post-concussion syndrome. Conducted at Poitiers University Hospital, the study will involve patients who are admitted for mild head trauma and will assess their condition seven days post-injury. The goal is to determine if this advanced imaging technique can improve diagnostic accuracy compared to standard methods. By identifying these lesions, the study seeks to better understand the relationship between brain injuries and persistent post-concussion symptoms.
Who should consider this trial
Good fit: Ideal candidates are individuals aged 18 and older who have sustained a mild traumatic brain injury and are experiencing post-concussion symptoms.
Not a fit: Patients with psychiatric disorders, severe obesity, or contraindications for MRI will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved diagnostic capabilities for post-concussion syndrome, potentially reducing long-term symptoms and associated healthcare costs.
How similar studies have performed: While there is emerging literature on the use of advanced MRI techniques for brain injury diagnosis, this specific approach using 7 Tesla MRI is relatively novel and has not been extensively tested in this context.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Mild traumatic brain injury with glascow included between 13 and 15, with indication of scan * possibilty of performing an MRI at 7 days * Patient able to get to MRI at Day 7 * Free consentement to the study * Any measure of guardianship or curatorship , any link of subordination Exclusion Criteria: * Patient does not hospitalized about head trauma * Inhability to move out for run the seven day MRI * Contraindication for MRI * Patient having already consulted the emergency for head trauma requiring imaging * Patients with psychiatric troubles : bipolarity, panic trouble, depressive trouble, schizophrenia * Patient already enrolled in the study * History of brain, tumor or neurosurgery * Untreated or poorly treated chronic vertigo * Untreated or poorly treated chronic migraines * Claustrophobia * BMI \> 40 * Refusal of consent to take part of the study * No social welfare or inhability to benefit of it by a third party * Patients with enhanced protection : minor aged under 18 ; person with freedom restriction by justice decision or administrative ; homeliving in health or social establishment ; adult in legal protection * Pregnant and nursing women
Where this trial is running
Poitiers
- CHU Poitiers — Poitiers, France (Recruiting)
Study contacts
- Study coordinator: Jeremy GUENEZAN, Dr
- Email: jeremy.guenezan@chu-poitiers.fr
- Phone: 05 49 44 44 44
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.