Using 68Ga-grazytracer PET to monitor immunotherapy responses in advanced soft tissue sarcomas

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study investigates the effectiveness of 68Ga-grazytracer PET/CT imaging in predicting the response to immunotherapy in patients with advanced soft tissue sarcomas. Participants will undergo imaging after three cycles of immunotherapy, and the results will be compared to standard histopathological and clinical assessments. The study aims to establish a correlation between imaging findings and treatment efficacy, potentially improving patient management in this challenging cancer type.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Pathological and clinical diagnosis of advanced soft tissue sarcomas, pathological types include: fibrosarcoma, liposarcoma, undifferentiated pleomorphic sarcoma, epithelioid sarcoma, rhabdomyosarcoma, synovial sarcoma, alveolar soft-part sarcoma, leiomyosarcoma, clear cell sarcoma, malignant schwannoma, angiosarcoma.
2. Consider immunotherapy or combined immunotherapy based on clinical judgement.
3. Signed and dated informed consent form.
4. Commitment to comply with research procedures and co-operation in the implementation of the full research process.
5. Aged 6-80 years old.

Exclusion Criteria:

1. Patients with serious illnesses that researchers consider unsuitable for participation in this clinical study. Such as severe heart and lung failure, severe bone marrow suppression, severe liver and kidney dysfunction, etc.
2. Intestinal perforation, complete intestinal obstruction
3. Pregnant women and women who may be pregnant, women who are breastfeeding.
4. Non-compliant person

Where it's running

• Ruijin Hospital affiliated to Shanghai Jiao Tong University of Medicine
  Shanghai, Shanghai Municipality, China Recruiting

Study contacts

• Study coordinator: Jiajia Hu
• Email: jiajiahu@shsmu.edu.cn
• Phone: 13524945287

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.