Using 40 Hz brain stimulation to reduce delirium after hip or knee surgery in older adults
The Effect of 40 Hz Transcranial Stimulation on the Incidence of Delirium After Total Hip Replacement or Total Knee Replacement Arthroplasty in Elderly Patients
This study is testing if a special brain stimulation can help older adults who have hip or knee surgery avoid confusion and recover better.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 110 (estimated) |
| Ages | 65 Years to 85 Years |
| Sex | All |
| Sponsor | Henan Provincial People's Hospital Academic / other |
| Locations | 1 site (Zhengzhou, Henan) |
| Trial ID | NCT06522087 on ClinicalTrials.gov |
What this trial studies
This study investigates the impact of 40 Hz transcranial stimulation on the occurrence of postoperative delirium in elderly patients undergoing total hip or knee replacement surgeries. Delirium is a serious condition that can affect recovery and quality of life, particularly in older adults. By applying 40 Hz stimulation, the study aims to enhance cognitive functioning and potentially decrease the incidence of delirium following surgery. The trial will include patients aged 65 to 85 who meet specific health criteria and will be conducted at Henan Provincial People's Hospital.
Who should consider this trial
Good fit: Ideal candidates are elderly patients aged 65-85 undergoing unilateral total hip or knee replacement surgery without prior mental health issues.
Not a fit: Patients with severe liver or kidney dysfunction, pre-existing mental health conditions, or those who have a history of delirium may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could significantly reduce the incidence of postoperative delirium, improving recovery outcomes for elderly patients.
How similar studies have performed: While the use of transcranial stimulation is a novel approach, similar studies have shown promise in improving cognitive outcomes in various populations.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1.65-85 years old, gender not limited 2.General anesthesia unilateral total hip replacement surgery or unilateral total knee replacement 3.ASA classification I-III 4.No drugs for mental and central nervous system diseases were used before surgery 5.Preoperative MMSE score illiterate \> 17 points, primary \> 20 points, junior high school and above \> 24 points 6.Obtaining informed consent Exclusion Criteria: 1. Severe liver and kidney dysfunction 2. here were mental and nervous system diseases before operation 3. Have a history of alcoholism, long-term use of sedative or analgesic 4. A history of a delirium and other reasons are reluctant to cooperate 5. Massive blood loss and blood transfusion during operation, prolonged operation time
Where this trial is running
Zhengzhou, Henan
- Henan People's Hospital — Zhengzhou, Henan, China (Recruiting)
Study contacts
- Study coordinator: Zhang jiaqiang
- Email: hnmzxh@163.com
- Phone: 037165580728
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.