Using 2D and 3D imaging to study bone regeneration after tooth extraction

Using 2D/3D Imaging to Analyze the Regeneration Rate of Autologous Bone During Alveolar Bone Preservation Surgery Using Periodontal Valves to Completely Cover Autologous Tooth Roots, Bone Substitutes, and Vitamin D3 Treatment

This study is testing a new way to help bones heal after a tooth is pulled by using pieces of the tooth and Vitamin D3 to see if it works better than regular methods.

Quick facts

• Phase: Not applicable
• Study type: Interventional
• Enrollment: 48 (estimated)
• Ages: 20 Years to 70 Years
• Sex: All
• Sponsor: Chang Gung Memorial Hospital (Academic / other)
• Locations: 1 site (Taoyuan)
• Trial ID: NCT06141239 on ClinicalTrials.gov

What this trial studies

This clinical trial investigates a novel approach to alveolar ridge preservation following tooth extraction by utilizing autologous tooth root slices and Vitamin D3. Participants will receive a collagen plug and bone graft materials in their extraction sockets to promote healing and bone formation. The study aims to analyze the regeneration rate of bone using advanced imaging techniques, which may provide insights into the effectiveness of this new method compared to traditional approaches. The trial is designed to assess the stability and healing of the extraction site, potentially improving outcomes for future dental implant placements.

Who should consider this trial

Good fit: Ideal candidates are individuals requiring tooth extraction in preparation for future dental implants, without systemic diseases that could impair healing.

Not a fit: Patients with conditions that weaken healing abilities, such as cancer, diabetes, or severe dental infections, may not benefit from this study.

Why it matters

Potential benefit: If successful, this approach could enhance bone regeneration and improve the predictability of dental implant placements for patients.

How similar studies have performed: While the use of collagen plugs and Vitamin D3 is established, the specific combination of autologous tooth root slices in this context is novel and has not been extensively tested in prior studies.

Eligibility criteria

Inclusion Criteria:

1. Willing to sign written subject consent
2. The tooth extraction socket is located in the anterior and posterior areas of the upper and lower jaws.
3. The area of the extraction socket (bone defect) in the mouth will need to be treated with artificial dental implants in the future.
4. The patient does not have systemic diseases (such as patients with hypertension, osteoporosis, bone-related diseases, kidney disease, thyroid and parathyroid diseases, etc.).

Exclusion Criteria:

1. Patients with potentially weakened healing abilities such as cancer, diabetes, bone infection, tuberculosis, anemia due to heme abnormalities or congenital immune deficiency, cellulitis, acute periodontal cyst, severe cusp disease (cyst size) \>2mm2) or patients with dental and jaw lesions.
2. Women who are pregnant or breastfeeding.
3. Exclude heavy smokers or betel nut chewers who smoke more than one pack of cigarettes per day.
4. The bone defect in the extraction socket is severe and requires other bone regeneration surgeries (GBR), otherwise it will not be possible to have enough volume to provide artificial dental implants in the future.

Where this trial is running

Taoyuan

• Chang Gung Memorial Hospital — Taoyuan, Taiwan (Recruiting)

Study contacts

• Study coordinator: Hsiang Hsi Hong

Conditions Alveolar Ridge Preservation