Using 2D and 3D imaging to study bone regeneration after tooth extraction

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates a novel approach to alveolar ridge preservation following tooth extraction by utilizing autologous tooth root slices and Vitamin D3. Participants will receive a collagen plug and bone graft materials in their extraction sockets to promote healing and bone formation. The study aims to analyze the regeneration rate of bone using advanced imaging techniques, which may provide insights into the effectiveness of this new method compared to traditional approaches. The trial is designed to assess the stability and healing of the extraction site, potentially improving outcomes for future dental implant placements.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Willing to sign written subject consent
2. The tooth extraction socket is located in the anterior and posterior areas of the upper and lower jaws.
3. The area of the extraction socket (bone defect) in the mouth will need to be treated with artificial dental implants in the future.
4. The patient does not have systemic diseases (such as patients with hypertension, osteoporosis, bone-related diseases, kidney disease, thyroid and parathyroid diseases, etc.).

Exclusion Criteria:

1. Patients with potentially weakened healing abilities such as cancer, diabetes, bone infection, tuberculosis, anemia due to heme abnormalities or congenital immune deficiency, cellulitis, acute periodontal cyst, severe cusp disease (cyst size) \>2mm2) or patients with dental and jaw lesions.
2. Women who are pregnant or breastfeeding.
3. Exclude heavy smokers or betel nut chewers who smoke more than one pack of cigarettes per day.
4. The bone defect in the extraction socket is severe and requires other bone regeneration surgeries (GBR), otherwise it will not be possible to have enough volume to provide artificial dental implants in the future.

Where it's running

• Chang Gung Memorial Hospital
  Taoyuan, Taiwan Recruiting

Study contacts

• Study coordinator: Hsiang Hsi Hong
• Email: f1214@adm.cgmh.org.tw
• Phone: +886975365989

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Effect of four post-extraction socket approaches on preserving the ridge after tooth removal

  This study tests four ways to care for an extraction socket to see which best preserves the jawbone and gum after tooth removal for future implants.

  Recruiting Universidad del Desarrollo · Santiago, Santiago Metropolitan · NCT07812883

• Bone-preserving grafting with Biphasic Calcium Phosphate after tooth extraction

  This trial tests whether Neobone biphasic calcium phosphate grafts help preserve bone volume in tooth extraction sites compared with natural healing.

  Recruiting Early Phase 1 Egas Moniz - Cooperativa de Ensino Superior, CRL · Caparica, Monte Da Caparica · NCT07638358

• Alveolar ridge preservation and whether it lowers the need for sinus floor elevation after upper back tooth extraction

  This project tries to see if filling the socket after removing upper back teeth reduces the chance you'll need a sinus lift before getting a dental implant.

  Recruiting Saint-Joseph University · Beirut, Beirut · NCT07526129

• Demineralized versus mineralized dentin grafts to preserve the upper back tooth ridge

  We will test whether demineralized or mineralized donor dentin grafts better preserve bone after removing a single upper back tooth in healthy adults.

  Recruiting Kafrelsheikh University · Kafr ash Shaykh · NCT07242313

• Biotivity A/C Plus Membrane for Alveolar Ridge Preservation after Tooth Extraction

  This study tests whether a human amnion chorion membrane helps healing and bone preservation better than a collagen membrane after extracting a back tooth and preparing the site for an implant.

  Recruiting Phase 4 University of Maryland, Baltimore · Baltimore, Maryland · NCT07091448

• Evaluation of allogenic dentin grafts for preserving alveolar ridge after tooth extraction

  This study is testing if using grafts from human teeth can help preserve the bone in the jaw after a tooth is taken out, making it easier for people to get dental implants later.

  Recruiting Phase 1/2 Jordan University Hospital · Amman · NCT06827665

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.