Urine extracellular vesicle biomarkers for people with low magnesium
Official title: The Study of Urinary Biomarkers in Patients With Hypomagnesemia
Run by University of Florida · NCT07056283 · Data updated 2026-11-12
We will test whether tiny particles in urine can reveal the kidney-related causes of low blood magnesium in adults with hypomagnesemia.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 99 Years |
| Sex | All |
| Enrollment | 15 (estimated) |
| Sponsor | University of Florida Academic / other |
| Locations | 1 site (Gainesville, Florida) |
| Status | Recruiting |
| Started | July 31, 2025 |
| Main results expected | June 2027 |
| Study ends | June 2027 |
| Registry record updated | August 24, 2025 |
| Trial ID | NCT07056283 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 18 or older with a documented history of hypomagnesemia (serum Mg < 1.7 mg/dL) who can provide multiple morning urine samples and are not taking excluded diuretics are ideal candidates.
✕Probably not a fit
People currently taking loop, thiazide, or thiazide-like diuretics within the past three months, or those without documented low magnesium, are unlikely to receive direct benefit from this observational biomarker study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a small, noninvasive pilot study collecting morning urine from up to 15 adults with a history of low blood magnesium, with up to 10 samples per person. Investigators will isolate urinary extracellular vesicles (uEVs) and perform multi-omics analyses including lipidomics, microRNA profiling, and phospho-proteomics to look for signatures linked to magnesium handling. Samples will include fasting and post–magnesium-rich meal collections taken in the morning, timed around recent serum magnesium measurements. The goal is to use uEV biomarkers to better understand renal mechanisms that cause hypomagnesemia.
Why it matters
Potential benefit: If successful, this approach could lead to a noninvasive urine test that helps pinpoint why a person is losing magnesium and guide more personalized treatment.
How similar studies have gone: Urinary extracellular vesicles have shown promise as biomarkers in other kidney research, but applying multi-omics specifically to explain hypomagnesemia is relatively novel and largely untested.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adult (≥18 years old) * History of hypomagnesemia (serum Mg \<1.7 mg/dL) Exclusion Criteria: * Current or recent use of loop, thiazide, or thiazide-like diuretics within the last 3 months
Where it's running
-
University of Florida
Gainesville, Florida, United States Recruiting
Study contacts
- Principal investigator: Chintan Shah, MD — University of Florida
- Study coordinator: Chintan Shah, MD
- Email: shahc@ufl.edu
- Phone: (352) 294-8790
Similar studies
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.