Understanding why some patients don't lose weight after bariatric surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study focuses on patients who have undergone bariatric surgery but are classified as 'poor responders,' meaning they either lose less weight than expected or regain weight after initial loss. The research aims to investigate the role of gut hormones in these patients to better understand their unique challenges. By identifying the factors that contribute to poor weight loss outcomes, the study seeks to develop targeted interventions to improve results for this specific group. Participants will include individuals aged 18-70 who have had bariatric surgery at least one year prior or are awaiting surgery.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Aged 18 -70 years.
* Male or female.
* Previous bariatric surgery for obesity and/or diabetes (studies 1 and 2).
* ≥1 year interval after bariatric surgery (studies 1 and 2).
* Awaiting bariatric surgery at the Imperial Weight Centre (study 3)
* Able to give informed consent.

Exclusion Criteria:

* History of any medical, psychological or other condition, or use of any medications, including over-the-counter products, which, in the opinion of the investigators, would either interfere with the study or potentially cause harm to the volunteer.
* Without access at home to a telephone or other factor likely to interfere with ability to participate reliably in the study.
* Pregnancy or breastfeeding.
* Unable to maintain adequate contraception for the duration of the study and for one month afterwards.
* History of hypersensitivity to any of the components of the subcutaneous infusions.
* Donated blood during the preceding 3 months or intention to do so before the end of the study.
* Any other co-morbidity that would compromise the validity of the study or the safety of the participant such as heart failure or clinically apparent cardiovascular disease.
* Anatomical or endocrinological pathology causing poor weight loss or weight regain
* Uncontrolled hypertension (systolic blood pressure of 160 mmHg or above and/or diastolic blood pressure of 100 mmHg or above)
* Participation in a research study within the last two months.
* Unable to speak English (this is relevant to answering the psychological questionnaires)

Where it's running

• Imperial College London
  London, United Kingdom Recruiting

Study contacts

• Principal investigator: Tricia M Tan, PhD — Imperial College London
• Study coordinator: Kleopatra Alexiadou, PhD
• Email: k.alexiadou@imperial.ac.uk
• Phone: +442033138038

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Characterizing diabetes and obesity in Greenlandic patients

  This study is trying to learn more about how genetics and environment affect type 2 diabetes and obesity in Greenlandic people, while also looking at related health issues like sleep apnea.

  Recruiting Steno Diabetes Center Greenland · Nuuk, Sermersooq · NCT06264427

• Understanding genetic factors that affect weight loss after bariatric surgery

  This study is trying to find out if certain genes can help predict how well people with severe obesity will lose weight after having bariatric surgery.

  Recruiting Institut de Recerca Biomèdica de Lleida · Lleida, Leida · NCT06226194

• Identifying predictors of weight loss and metabolic health after bariatric surgery

  This study is trying to find out what factors can help predict how well people with insulin resistance will lose weight and improve their health after having bariatric surgery.

  Recruiting Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) · Gouda, South Holland and 2 other locations · NCT05987631

• Survey on bariatric surgery for adolescents

  This study is trying to see how well laparoscopic adjustable gastric banding works for teenagers aged 14-20 who are having bariatric surgery, focusing on weight loss and any health issues that might come up.

  Recruiting University Hospital, Angers · Angers, Maine Et Loire · NCT04766801

• Registry for bariatric surgery quality control

  This study is setting up a registry to track the results and safety of bariatric surgery for people who are severely obese to help improve surgical practices.

  Recruiting Sheba Medical Center · Ramat Gan · NCT04040413

• Impact of Bariatric Surgery on Bone Health in Type 2 Diabetes Patients

  This study is testing how sleeve gastrectomy surgery affects bone health in people with type 2 diabetes compared to those who are overweight but don’t have diabetes.

  Recruiting CHU de Quebec-Universite Laval · Montreal, Quebec and 2 other locations · NCT03455868

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.