Understanding valve disease in patients with atrial fibrillation

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational cohort study aims to identify clinical phenotypes and evaluate predictors and outcomes of functional mitral and tricuspid valve regurgitation in patients diagnosed with atrial fibrillation. Participants will undergo baseline echocardiography, blood tests, and follow-up echocardiography over one year. The study will stratify participants into three subgroups based on their valve disease: atrial functional mitral regurgitation, atrial functional tricuspid regurgitation, and mixed disease. The primary objective is to characterize these phenotypes and identify risk factors for disease progression.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Informed consent
* Age of 18 years or older
* Atrial fibrillation
* Moderate or severe atrial valve disease
* Adequate 2D echocardiography views including parasternal long axis, short axis, apical two chamber, apical three chamber and four chamber.

Exclusion Criteria:

* Unwilling or unable to give consent
* Left ventricular impairment (ejection fraction \< 50%).
* Primary/organic valve disease

Where it's running

• St Bartholomew's Hospital
  London, United Kingdom Recruiting

Study contacts

• Principal investigator: Sanjeev bhattacharyya — Barts & The London NHS Trust
• Study coordinator: Jawza Aldakhil
• Email: Jawza@outlook.sa
• Phone: 00447899770693

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.