Understanding Urinary Tract Infections in General Practice

Profiles of Urinary Tract Infections in General Practice : a Prospective Multicentre Cohort Study

This study is trying to understand different types of urinary tract infections in general practice to help doctors provide better treatment and guidelines for patients.

Quick facts

• Study type: Observational
• Enrollment: 500 (estimated)
• Ages: 18 Years and up
• Sex: All
• Sponsor: CNGE Conseil (Academic / other)
• Locations: 1 site (Saint-Maur-des-Fossés, Saint Maur)
• Trial ID: NCT05847036 on ClinicalTrials.gov

What this trial studies

This observational study aims to explore the various profiles of urinary tract infections (UTIs) encountered in general practice, beyond the typical classifications of cystitis and pyelonephritis. It seeks to identify intermediate forms of UTIs that may lead to longer durations of antibiotic therapy and to uncover factors contributing to these variations. By analyzing clinical signs and urine test results from patients presenting with UTI symptoms, the study aims to develop more tailored guidelines for managing UTIs in primary care settings.

Who should consider this trial

Good fit: Ideal candidates for this study are adults aged 18 and older presenting with clinical signs suggestive of urinary tract infections.

Not a fit: Patients under 18 years old, those with indwelling urinary catheters, or those who are pregnant may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could lead to improved management and treatment guidelines for urinary tract infections, potentially reducing antibiotic resistance.

How similar studies have performed: While there is existing literature on UTIs, this study's focus on intermediate forms in general practice is relatively novel and has not been extensively tested.

Eligibility criteria

Inclusion Criteria:

* Patient ≥18 years old
* Patient presenting one or more of the following clinical signs suggestive of urinary tract infection in general practice consultation:

  * fever (temperature \> 38°C)
  * chills, sweats
  * burning urination
  * urinary urgency
  * pollakiuria
  * dysuria
  * lumbar and/or pelvic pain
  * abnormal urine appearance: cloudy, malodorous, macroscopic haematuria
  * absence of leucorrhoea
  * specifically in people \> 70 years old:

    * recent onset urinary incontinence
    * sudden confusion
    * bladder globe
* Positive urine dipstick and/or positive Cytobacteriological Examination of Urine (CBEU)
* Patient affiliated with the French National Health Insurance or beneficiary of such a scheme.
* Patient's oral non-opposition of participation in the study after receiving complete information about the protocol

Non-inclusion Criteria:

* Patient \< 18 years old
* Declared pregnancy
* Patient with indwelling urinary catheter
* Patient with functional or organic abnormality of the urinary tract
* Patient with known severe immunodeficiency (HIV+ with CD4 count \< 200/mm3, organ transplant, bone marrow transplant, patient on immunosuppressants, cirrhosis)
* Patient with known severe chronic renal failure (clearance \< 30 mL/min)
* Patient previously treated with an antibiotic (for an other reason than a urinary tract infection and/or treatment failure of the urinary tract infection) in the past month before the inclusion consultation
* Patient speaking little or no French
* Patient with severe cognitive impairment
* Patient with life expectancy \< 3 months
* Patient under legal protection, inability to give an oral non-opposition
* Patient with severity criteria justifying hospitalization

Where this trial is running

Saint-Maur-des-Fossés, Saint Maur

• Cabinet de groupe — Saint-Maur-des-Fossés, Saint Maur, France (Recruiting)

Study contacts

• Principal investigator: Véronique ORCEL, Dr — Département Universitaire d'Enseignement et de Recherche de Médecine Générale de Créteil
• Study coordinator: Véronique ORCEL, Dr

Conditions Urinary Tract Infections