Understanding tumor variations in peritoneal cancers
PITCHER (Peritoneal Carcinomatosis Heterogeneity)
This study is trying to understand how changes in genes affect different types of peritoneal cancers, like colorectal and ovarian, by collecting data from patients who have had surgery for these cancers.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 20 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Hospices Civils de Lyon Academic / other |
| Locations | 1 site (Lyon) |
| Trial ID | NCT04714957 on ClinicalTrials.gov |
What this trial studies
This observational study investigates how epigenetic changes affect gene expression in different subclones of peritoneal carcinomatosis, particularly in colorectal and ovarian cancers. It aims to collect data and specimens from patients who have undergone surgery for this condition, focusing on the variations in gene expression and how these changes relate to the cancer's adaptation to its environment. The study involves a collaboration of 10 research teams from Lyon, Grenoble, and Marseille, creating a comprehensive database of genetic and epigenetic information.
Who should consider this trial
Good fit: Ideal candidates are adults over 18 years old with histologically or radiologically confirmed peritoneal carcinomatosis of colorectal or ovarian origin.
Not a fit: Patients who do not have peritoneal carcinomatosis or those with other unrelated cancers may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved understanding of cancer behavior and potentially inform more effective treatment strategies for patients with peritoneal carcinomatosis.
How similar studies have performed: While the specific approach of this study may be novel, similar studies investigating tumor heterogeneity and epigenetic factors have shown promise in understanding cancer dynamics.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients who accept to participate to the study * Men / women aged over 18 years * Patients with cancer management and care for peritoneal carcinomatosis of digestive or ovarian origin * Patients had histologic/radiologic confirmation of peritoneal disease * Serology negative HIV, HEPATITIS Exclusion Criteria: • none
Where this trial is running
Lyon
- Lyon SUD Hospital, Hospices Civils de Lyon — Lyon, France (Recruiting)
Study contacts
- Study coordinator: Olivier GLEHEN, MD
- Email: olivier.glehen@chu-lyon.fr
- Phone: +33 4 78 86 23 71
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.