Understanding the tumor microenvironment in children's solid tumors to improve adoptive cell therapy

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational project collects and analyzes tumor samples from pediatric patients with a range of solid tumors to map immune and cellular features of the tumor microenvironment. Researchers preserved primary cells from 42 neoplasms representing neuroblastomas, sarcomas, nephroblastomas, lymphomas, teratomas and other rare pediatric tumors and stabilized five cell lines for laboratory studies. The team is using these materials, together with tumor-specific cytotoxic T lymphocyte lines derived from healthy adult donors, to test how tumor antigens and local immune conditions influence T cell responses in vitro. Results are intended to identify targetable antigens and microenvironmental barriers that could inform the design of more effective adoptive cell therapies for children.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* pediatric patients 0-18 years
* affected by solid tumors

Exclusion Criteria:

* patients over 18
* non-solid malignancies

Where it's running

• Fondazione IRCCS Policlinico San Matteo, SC Chirurgia Pediatrica
  Pavia, Pavia, Italy Recruiting

Study contacts

• Study coordinator: Mirko Bertozzi, MD
• Email: m.bertozzi@smatteo.pv.it
• Phone: +393393196807

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.