Understanding the timing of motor and nonmotor symptoms in Parkinson's disease
Official title: Temporal Relationship Between Motor Fluctuations and Nonmotor Fluctuations
Run by Seoul National University Hospital · NCT02060695 · Data updated 2026-11-12
This study looks at how movement and non-movement symptoms change over time in people with early-stage Parkinson's disease to see which ones happen first.
Quick facts
| Study type | Observational |
|---|---|
| Sex | All |
| Enrollment | 800 (estimated) |
| Sponsor | Seoul National University Hospital Academic / other |
| Locations | 1 site (Seoul) |
| Status | Recruiting |
| Started | September 2012 |
| Main results expected | June 2030 |
| Study ends | June 2031 |
| Registry record updated | May 3, 2017 |
| Trial ID | NCT02060695 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are individuals diagnosed with early-stage Parkinson's disease who do not currently experience motor or nonmotor fluctuations.
✕Probably not a fit
Patients with dementia or those who refuse to participate may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to explore the relationship between motor fluctuations and nonmotor fluctuations in individuals diagnosed with early-stage Parkinson's disease. It will track how many patients experience these fluctuations during a three-year follow-up period and determine whether motor fluctuations occur before or after nonmotor fluctuations. The study will involve participants who meet specific diagnostic criteria and are not experiencing significant fluctuations at the start. Data will be collected over a three-year recruitment and follow-up period.
Why it matters
Potential benefit: If successful, this study could enhance understanding of symptom progression in Parkinson's disease, potentially leading to improved management strategies.
How similar studies have gone: While there have been studies on motor and nonmotor symptoms in Parkinson's disease, this specific temporal relationship has not been extensively explored, making this approach relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * clinical diagnosis of Parkinson disease by United Kingdom Parkinson's Disease Society Brain Bank criteria * early stage Exclusion Criteria: * dementia (MMSE\<26) * persons who refuse participating
Where it's running
-
Seoul National University Hospital
Seoul, South Korea Recruiting
Study contacts
- Principal investigator: Beom S Jeon, MD, PhD — Seoul National University Hospital
- Study coordinator: Beom S Jeon, MD, PhD
- Email: brain@snu.ac.kr
- Phone: 82-2-2072-2876
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.