Clinical trial Recruiting at 1 site Observational

Understanding the timing of motor and nonmotor symptoms in Parkinson's disease

Official title: Temporal Relationship Between Motor Fluctuations and Nonmotor Fluctuations

Run by Seoul National University Hospital · NCT02060695 · Data updated 2026-11-12

This study looks at how movement and non-movement symptoms change over time in people with early-stage Parkinson's disease to see which ones happen first.

More Parkinson Disease trials

Quick facts

Study typeObservational
SexAll
Enrollment800 (estimated)
SponsorSeoul National University Hospital
Academic / other
Locations1 site (Seoul)
StatusRecruiting
StartedSeptember 2012
Main results expectedJune 2030
Study endsJune 2031
Registry record updatedMay 3, 2017
Trial IDNCT02060695 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are individuals diagnosed with early-stage Parkinson's disease who do not currently experience motor or nonmotor fluctuations.

Probably not a fit

Patients with dementia or those who refuse to participate may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to explore the relationship between motor fluctuations and nonmotor fluctuations in individuals diagnosed with early-stage Parkinson's disease. It will track how many patients experience these fluctuations during a three-year follow-up period and determine whether motor fluctuations occur before or after nonmotor fluctuations. The study will involve participants who meet specific diagnostic criteria and are not experiencing significant fluctuations at the start. Data will be collected over a three-year recruitment and follow-up period.

Why it matters

Potential benefit: If successful, this study could enhance understanding of symptom progression in Parkinson's disease, potentially leading to improved management strategies.

How similar studies have gone: While there have been studies on motor and nonmotor symptoms in Parkinson's disease, this specific temporal relationship has not been extensively explored, making this approach relatively novel.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* clinical diagnosis of Parkinson disease by United Kingdom Parkinson's Disease Society Brain Bank criteria
* early stage

Exclusion Criteria:

* dementia (MMSE\<26)
* persons who refuse participating

Where it's running

  • Seoul National University Hospital
    Seoul, South Korea
    Recruiting

Study contacts

  • Principal investigator: Beom S Jeon, MD, PhD — Seoul National University Hospital
  • Study coordinator: Beom S Jeon, MD, PhD
  • Email: brain@snu.ac.kr
  • Phone: 82-2-2072-2876

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.