Understanding the timing of motor and nonmotor symptoms in Parkinson's disease
Temporal Relationship Between Motor Fluctuations and Nonmotor Fluctuations
This study looks at how movement and non-movement symptoms change over time in people with early-stage Parkinson's disease to see which ones happen first.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 800 (estimated) |
| Sex | All |
| Sponsor | Seoul National University Hospital Academic / other |
| Locations | 1 site (Seoul) |
| Trial ID | NCT02060695 on ClinicalTrials.gov |
What this trial studies
This observational study aims to explore the relationship between motor fluctuations and nonmotor fluctuations in individuals diagnosed with early-stage Parkinson's disease. It will track how many patients experience these fluctuations during a three-year follow-up period and determine whether motor fluctuations occur before or after nonmotor fluctuations. The study will involve participants who meet specific diagnostic criteria and are not experiencing significant fluctuations at the start. Data will be collected over a three-year recruitment and follow-up period.
Who should consider this trial
Good fit: Ideal candidates are individuals diagnosed with early-stage Parkinson's disease who do not currently experience motor or nonmotor fluctuations.
Not a fit: Patients with dementia or those who refuse to participate may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance understanding of symptom progression in Parkinson's disease, potentially leading to improved management strategies.
How similar studies have performed: While there have been studies on motor and nonmotor symptoms in Parkinson's disease, this specific temporal relationship has not been extensively explored, making this approach relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * clinical diagnosis of Parkinson disease by United Kingdom Parkinson's Disease Society Brain Bank criteria * early stage Exclusion Criteria: * dementia (MMSE\<26) * persons who refuse participating
Where this trial is running
Seoul
- Seoul National University Hospital — Seoul, South Korea (Recruiting)
Study contacts
- Principal investigator: Beom S Jeon, MD, PhD — Seoul National University Hospital
- Study coordinator: Beom S Jeon, MD, PhD
- Email: brain@snu.ac.kr
- Phone: 82-2-2072-2876
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.