Understanding the role of the sympathetic nervous system in rosacea
Role of the Sympathetic Nervous System in Rosacea
This study is trying to see how stress affects blood flow and nerve activity in people with rosacea to help find better treatments for the condition.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 210 (estimated) |
| Ages | 18 Years to 45 Years |
| Sex | All |
| Sponsor | University of Kentucky Academic / other |
| Locations | 2 sites (Indianapolis, Indiana and 1 other locations) |
| Trial ID | NCT03989492 on ClinicalTrials.gov |
What this trial studies
This study investigates the involvement of the sympathetic nervous system in rosacea, a common skin condition characterized by facial redness and inflammation. It aims to explore how stressors affect skin blood flow and sympathetic nerve activity in individuals with rosacea compared to healthy controls. By examining these mechanisms, the study seeks to enhance the understanding of rosacea and potentially lead to improved treatment options for affected patients.
Who should consider this trial
Good fit: Ideal candidates include otherwise healthy males and non-pregnant/non-lactating females with mild to moderate erythematotelangiectatic rosacea.
Not a fit: Patients with significant comorbidities or those currently using medications that affect neural or cardiovascular responses may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to better-targeted therapies for managing rosacea symptoms.
How similar studies have performed: While this study explores a relatively novel approach, previous pilot studies have suggested sympathetic dysfunction in rosacea, indicating potential for success.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Otherwise healthy males and non-pregnant/non-lactating females with mild to moderate erythematotelangiectactic rosacea, as well as age-sex matched healthy control subjects. Exclusion Criteria: * Neurological, cardiovascular, respiratory, metabolic, muscular, or other dermatological disorders * Current history of alcohol and/or drug abuse * Known allergies or hypersensitivities to medications/drugs that are used in the protocol * Current smoking or regular smoking within the last 2 years * Body mass index \> 35 kg/m2 * Medications or supplements which are known to affect neural, cardiovascular, or muscular responses
Where this trial is running
Indianapolis, Indiana and 1 other locations
- Indiana University — Indianapolis, Indiana, United States (Completed)
- University of Kentucky — Lexington, Kentucky, United States (Recruiting)
Study contacts
- Principal investigator: Kristen Metzler-Wilson, PT, PhD — University of Kentucky
- Study coordinator: Kristen Metzler-Wilson, PT, PhD
- Email: kristen.metzler@uky.edu
- Phone: 859-218-0833
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.