Understanding the Role of Myelin in Brain Function During Adolescence

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to explore the relationship between myelin levels in the brain and cognitive control functions in adolescents and young adults. Using non-invasive Magnetic Resonance Imaging (MRI), researchers will assess the microstructural properties of myelin and its impact on cognitive abilities associated with the prefrontal cortex. Participants aged 10 to 25 will undergo clinical examinations, MRI scans, and cognitive assessments to gather data on how myelin influences executive control during critical developmental stages. The findings could provide insights into brain development and cognitive functioning.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Male or female; Subject aged 10 to 25 years; Right-handed preference; Subject, or legal representative, who has given consent to participate; Native language: French; Subject affiliated with a social security system; Having signed their consent to participate (and their legal representative if applicable), subjects and parents have read the information letter and given their free and informed consent. In cases where only one parent gives consent (for minors), this must be justified (such as no contact with the other parent for over a year).

Exclusion Criteria:

* Not corresponding to the targeted age range;
* Subject with contraindications to an MRI examination (pacemaker or neurosensory stimulator or implantable defibrillator, cochlear implants, ferromagnetic foreign bodies in the eyes or brain near neural structures, metal prostheses, patient agitation: non-cooperative or agitated patients, minors, claustrophobic subjects, pregnant women, ventriculoperitoneal neurosurgical shunt valves, dental braces);
* Subject with chronic alcohol or drug use;
* Abuse or dependence on substances (except nicotine) or toxic substances for more than 5 years or having led to comas (overdoses);
* Subject with sudden-onset cognitive disorders that could indicate a stroke; a history of head trauma with loss of consciousness for more than 1 hour, or encephalitis;
* Subject with chronic neurological, psychiatric, endocrine, hepatic, or infectious conditions;
* Subject with a history of major illness (diabetes, chronic lung disease, severe cardiac, metabolic, hematological, endocrine, or immunological disorder, cancer);
* Subject on medication: taking medications likely to interfere with brain imaging measurements (psychotropics, anxiolytic hypnotics, neuroleptics, anti-Parkinsonians, benzodiazepines, steroidal anti-inflammatories, antiepileptics, central analgesics, and muscle relaxants);
* Color blindness;
* Inability to comply with the study for geographical or psychiatric reasons;
* Tattoo incompatible with MRI;
* Cerebral palsy;
* Fine motor skills disorder;
* Pregnant women at the time of inclusion;
* Adult subjects under legal protection or unable to give consent (article L.1121-8 of the French Public Health Code) (under guardianship or curatorship);
* Children and parents under legal protection measures

Where it's running

• GHU Ste Anne
  Paris, France Recruiting

Study contacts

• Study coordinator: Arnaud Cachia
• Email: arnaud.cachia@u-paris.fr
• Phone: 06 61 51 92 00

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.